SBI-797812

製品コードS8980 バッチS898001

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₉H₂₂N₄O₄S

分子量

402.47

CAS No.

2237268-08-3

Solubility (25°C)*

体外

DMSO

80 mg/mL (198.77 mM)

Ethanol

2.5 mg/mL (6.21 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	4.000mg/ml (9.94mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.660mg/ml (1.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 13.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" that more efficiently generates NMN.
in vitro	SBI-797812 shifts the NAMPT reaction equilibrium towards nicotinamide mononucleotide formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. Treatment of cultured cells with this compound increases intracellular nicotinamide mononucleotide and NAD+.^[1]
in vivo	Plasma concentrations of SBI-797812 after oral administration are low. Higher plasma levels of this compound are seen after i.p. dosing. The potency of this chemical against mouse NAMPT is investigated. The apparent affinity (EC50) of this agent for mouse NAMPT is approximately 8-fold less than for human NAMPT, whereas maximal fold activation by this compound is comparable between the mouse and human NAMPT. Dosing of mice with this chemical elevates liver NAD+.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human A549 lung carcinoma cells
	濃度	10 μM
	反応時間	4 h
	実験の流れ	Human A549 lung carcinoma cells are grown in DMEM, 4.5 g l−1 D-(+)-glucose, 10% fetal bovine serum, penicillin/streptomycin mixture; 10 cm dishes and treated with DMSO (vehicle control) or SBI-797812 for 4 h.
動物実験	動物モデル	8-week-old male C57BL/6 J mice
	投薬量	10 mg/kg, 20 mg/kg
	投与方法	Oral gavage, IP

参考

https://pubmed.ncbi.nlm.nih.gov/31324777/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Use of single analytic tool to quantify both absolute N-glycosylation and glycan distribution in monoclonal antibodies [ Biotechnol Prog, 2023, e3365.]	PubMed: 37221987

Use of single analytic tool to quantify both absolute N-glycosylation and glycan distribution in monoclonal antibodies [ Biotechnol Prog, 2023, e3365.]

PubMed: 37221987

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。