Schisandrin B

製品コードS3600 バッチS360002

印刷

化学情報

Chemical Structure Synonyms Sch B Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C23H28O6
分子量 400.46 CAS No. 61281-37-6
Solubility (25°C)* 体外 DMSO 80 mg/mL (199.77 mM)
Ethanol 10 mg/mL (24.97 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
in vitro Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. [1] This compound decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of this compound on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. [2] It is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance. [3] [4]
in vivo Schisandrin B can protect liver against toxicant challenge. This compound pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. [5] [6] [7] Further studies demonstrate the protective effect of this chemical on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. [8] Moreover, it is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. [9]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/15378770/
  • https://pubmed.ncbi.nlm.nih.gov/19625493/
  • https://pubmed.ncbi.nlm.nih.gov/16084496/
  • https://pubmed.ncbi.nlm.nih.gov/7480197/
  • https://pubmed.ncbi.nlm.nih.gov/8891674/
  • https://pubmed.ncbi.nlm.nih.gov/11525242/
  • https://pubmed.ncbi.nlm.nih.gov/16889754/
  • https://pubmed.ncbi.nlm.nih.gov/21111034/
  • https://pubmed.ncbi.nlm.nih.gov/22848381/
  • https://pubmed.ncbi.nlm.nih.gov/16084496/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury [ Phytomedicine, 2025, 141:156672] PubMed: 40220406
Schisandrin B downregulates exosomal fibronectin 1 expression to inhibit hepatocellular carcinoma growth [ Front Pharmacol, 2025, 16:1547685] PubMed: 40223922
Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest [ Sci Rep, 2025, 15(1):8452] PubMed: 40069371
Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis [ Drug Des Devel Ther, 2024, 18:4241-4256] PubMed: 39323973
Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19 [ Viruses, 2022, 14(2)353] PubMed: 35215943
Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation [ Pharmacol Res, 2021, 166:105459] PubMed: 33545313
Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARγ [ Ann Transl Med, 2021, 9(19):1500] PubMed: 34805362
Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice [ Drug Dev Res, 2021, 10.1002/ddr.21905] PubMed: 34927282
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition [ Neurol Res, 2020, 42(8):693-702] PubMed: 32657248
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。