Schizandrol A

製品コードS3823 バッチS382301

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₄H₃₂O₇
	分子量	432.51	CAS No.	7432-28-2
Solubility (25°C)*	体外	DMSO	86 mg/mL (198.83 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
in vivo	Schizandrol A could improve the learning-memory dysfunction in mice induced by sodium pentobarbital intraperitoneally injected, and its protective mechanism is related to the effect of lowering oxidative damage and inhibiting the cell apoptosis through up-regulating the expression of Bcl-2 and down-regulating the expression of bax and improving the synthesis of neurotransmitters through increasing the expression of ChAT in the hippocampal CA1 region^[2].

製品説明

Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.

in vivo

Schizandrol A could improve the learning-memory dysfunction in mice induced by sodium pentobarbital intraperitoneally injected, and its protective mechanism is related to the effect of lowering oxidative damage and inhibiting the cell apoptosis through up-regulating the expression of Bcl-2 and down-regulating the expression of bax and improving the synthesis of neurotransmitters through increasing the expression of ChAT in the hippocampal CA1 region^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	The SH-SY5Y neuronal cell line
	濃度	1 or 3 μg/ml
	反応時間	4 d
	実験の流れ	After 24 h of incubation with or without schisandrin treatment, SH-SY5Y cells are seeded onto 96-well culture plates. Metallothionein (MTT) is added and absorbance values are continually measured for 4 d. All assays are conducted in triplicate. Data are expressed as percent viability. Rate of SH-SY5Y cells proliferation is calculated from optical density (OD) values.
動物実験	動物モデル	Mice
	投薬量	0.5, 1.0, 2.0 g/kg/d
	投与方法	by oral gavage

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。