Scutellarin

製品コードS3810 バッチS381001

化学情報

	Synonyms	Breviscapine, Breviscapin, Scutellarein-7-glucuronide	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₁₈O₁₂
	分子量	462.36	CAS No.	27740-01-8
Solubility (25°C)*	体外	DMSO	50 mg/mL (108.14 mM)
		Water	2 mg/mL (4.32 mM)

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
in vitro	Scutellarin protects PC12 cells against H2O2-induced cytotoxicity. It attenuates H2O2-induced intracellular accumulation of ROS and lipid peroxidation^[3]. Scutellarin shows negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 μM, whereas it shows values of 63.8 μM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 μM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively. Scutellarin also has weak inhibitory effect on P-gp^[4]. Scutellarin strongly induces MMP-2 activation and mRNA expression in cultured HUVECs in a concentration-dependent manner. It promotes angiogenesis and may form a basis for angiogenic therapy^[5].
in vivo	The pharmacokinetic results indicate that scutellarin undergoes rapid and extensive biotransformation in vivo. After intraperitoneal injection. scutellarin is absorbed rapidly. The relative bioavailability of oral administration is very low (10.67 %±4.78 %)^[1]. Scutellarin has a series of protective effects including dilate blood vessels, improving microcirculation, decreasing the viscosity of blood, reducing the blood platelet count, inhibiting platelet aggregation activity etc^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	PC12 cells
	濃度	1 and 10 μmol/L
	反応時間	30 min
	実験の流れ	Experiments are carried out 24-48 h after the cells are seeded into plates or dishes. To produce an oxidative stress, H2O2 is freshly prepared from a 30% stock solution prior to each experiment. Preincubation of cells with scutellarin is conducted for 30 min before H2O2 is added. Assays for cell viability, ROS, lipid peroxide, and apoptosis are performed at 6 or 12 h after addition of H2O2.
動物実験	動物モデル	Male Wistar rats
	投薬量	0.09, 0.17, 0.35, 0.70, 1.40 mmol/kg
	投与方法	oral

参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction [ Biomed Pharmacother, 2022, 155:113781]	PubMed: 36271561

Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction [ Biomed Pharmacother, 2022, 155:113781]

PubMed: 36271561

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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