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Synonyms | Breviscapine, Breviscapin, Scutellarein-7-glucuronide | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C21H18O12 |
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分子量 | 462.36 | CAS No. | 27740-01-8 | ||||
Solubility (25°C)* | 体外 | DMSO | 92 mg/mL (198.97 mM) | ||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. |
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in vitro | Scutellarin protects PC12 cells against H2O2-induced cytotoxicity. It attenuates H2O2-induced intracellular accumulation of ROS and lipid peroxidation[3]. Scutellarin shows negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 μM, whereas it shows values of 63.8 μM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 μM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively. Scutellarin also has weak inhibitory effect on P-gp[4]. Scutellarin strongly induces MMP-2 activation and mRNA expression in cultured HUVECs in a concentration-dependent manner. It promotes angiogenesis and may form a basis for angiogenic therapy[5]. |
in vivo | The pharmacokinetic results indicate that scutellarin undergoes rapid and extensive biotransformation in vivo. After intraperitoneal injection. scutellarin is absorbed rapidly. The relative bioavailability of oral administration is very low (10.67 %±4.78 %)[1]. Scutellarin has a series of protective effects including dilate blood vessels, improving microcirculation, decreasing the viscosity of blood, reducing the blood platelet count, inhibiting platelet aggregation activity etc[2]. |
細胞アッセイ | 細胞株 | PC12 cells |
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濃度 | 1 and 10 μmol/L | |
反応時間 | 30 min | |
実験の流れ | Experiments are carried out 24-48 h after the cells are seeded into plates or dishes. To produce an oxidative stress, H2O2 is freshly prepared from a 30% stock solution prior to each experiment. Preincubation of cells with scutellarin is conducted for 30 min before H2O2 is added. Assays for cell viability, ROS, lipid peroxide, and apoptosis are performed at 6 or 12 h after addition of H2O2. |
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動物実験 | 動物モデル | Male Wistar rats |
投薬量 | 0.09, 0.17, 0.35, 0.70, 1.40 mmol/kg | |
投与方法 | oral |
Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction [ Biomed Pharmacother, 2022, 155:113781] | PubMed: 36271561 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。