SGC-CBP30

製品コードS7256 バッチS725604

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₈H₃₃ClN₄O₃

分子量

509.04

CAS No.

1613695-14-9

Solubility (25°C)*

体外

DMSO

100 mg/mL (196.44 mM)

Ethanol

100 mg/mL (196.44 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.500mg/ml (4.91mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
in vitro	As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells. ^[1]
特徴	CREBBP/EP300-selective chemical probe.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	COLO-320-HSR cells
	濃度	20 μM
	反応時間	6 h
	実験の流れ	Cells were then treated for 6 hours with 20μM SGC-SCP30 or DMSO.
動物実験	動物モデル	Sprague-Dawley rats
	投薬量	25 mg/kg
	投与方法	p.o.

参考

http://www.thesgc.org/chemical-probes/CBP30
https://pubmed.ncbi.nlm.nih.gov/34819668/
https://pubmed.ncbi.nlm.nih.gov/30119248/

カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 175(1):186-199]

: Data from [Data independently produced by , , J Proteome Res, 2017, 16:1743−1752]

: Data from [Data independently produced by , , Biomed Pharmacother, 2018, 106:1727-1733]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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