SIS3

製品コードS3552 バッチS355201

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₈H₂₇N₃O₃

分子量

453.53

CAS No.

1009104-85-1

Solubility (25°C)*

体外

DMSO

91 mg/mL (200.64 mM)

Ethanol

91 mg/mL (200.64 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/16288083/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon [ J Virol, 2025, 99(9):e0043525]	PubMed: 40905682
Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC [ Life Sci Alliance, 2024, 7(6)e202302408]	PubMed: 38527804
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157]	PubMed: 37790250
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157]	PubMed: 37790250
Transforming growth factor-β1 promotes early odontoblastic differentiation of dental pulp stem cells via activating AKT, Erk1/2 and p38 MAPK pathways [ J Dent Sci, 2023, 18(1):87-94]	PubMed: 36643229
Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression [ Mol Cancer, 2022, 21(1):77]	PubMed: 35303882
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation [ Cells, 2022, 11(3)530]	PubMed: 35159339
Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion [ Cancers (Basel), 2022, 14(11)2751]	PubMed: 35681731
Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway [ Front Endocrinol (Lausanne), 2022, 13:1013018]	PubMed: 36714584
Sodium Fluoride and Sulfur Dioxide Derivatives Induce TGF-β1-Mediated NBCe1 Downregulation Causing Acid-Base Disorder of LS8 Cells [ Biol Trace Elem Res, 2022, 10.1007/s12011-022-03169-8]	PubMed: 35304687

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。