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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C28H27N3O3 |
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分子量 | 453.53 | CAS No. | 1009104-85-1 | |
Solubility (25°C)* | 体外 | DMSO | 91 mg/mL (200.64 mM) | |
Ethanol | 91 mg/mL (200.64 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. |
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Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157] | PubMed: 37790250 |
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression [ Front Bioeng Biotechnol, 2023, 11:1281157] | PubMed: 37790250 |
Transforming growth factor-β1 promotes early odontoblastic differentiation of dental pulp stem cells via activating AKT, Erk1/2 and p38 MAPK pathways [ J Dent Sci, 2023, 18(1):87-94] | PubMed: 36643229 |
Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression [ Mol Cancer, 2022, 21(1):77] | PubMed: 35303882 |
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation [ Cells, 2022, 11(3)530] | PubMed: 35159339 |
Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion [ Cancers (Basel), 2022, 14(11)2751] | PubMed: 35681731 |
Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway [ Front Endocrinol (Lausanne), 2022, 13:1013018] | PubMed: 36714584 |
Sodium Fluoride and Sulfur Dioxide Derivatives Induce TGF-β1-Mediated NBCe1 Downregulation Causing Acid-Base Disorder of LS8 Cells [ Biol Trace Elem Res, 2022, 10.1007/s12011-022-03169-8] | PubMed: 35304687 |
Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways [ Biomed Pharmacother, 2021, 143:112204] | PubMed: 34560552 |
CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation [ Int J Mol Sci, 2021, 23(1)375] | PubMed: 35008801 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。