Skatole

製品コードS4959 バッチS495901

化学情報

	Synonyms	3-methylindole, Scatole	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₉H₉N
	分子量	131.17	CAS No.	83-34-1
Solubility (25°C)*	体外	DMSO	26 mg/mL (198.21 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
in vivo	3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)^[2].

製品説明

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

in vivo

3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Pig hepatocytes
	濃度	0.5 mM
	反応時間	24 h
	実験の流れ	Cells were pre-incubated for 24 h prior to addition of acetone or skatole. A total of 17 mM acetone or 0.5 mM skatole (final concentration) were added and cells were incubated for further 24 h. Control cells were treated similarly except that no acetone or skatole was added.
動物実験	動物モデル	Fifteen adult grade ponies (aged 2 to approximately 20 years; mean weight, 177.1 kg)
	投薬量	100 mg/kg
	投与方法	nasogastric intubation

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Natural Product Skatole Ameliorates Lipotoxicity-Induced Multiple Hepatic Damage under Hyperlipidemic Conditions in Hepatocytes [ Nutrients, 2023, 15(6)1490]	PubMed: 36986221
Activation of PGRN/MAPK axis stimulated by the hypoxia-conditioned mesenchymal stem cell-derived HIF-1α facilitates osteosarcoma progression [ Exp Cell Res, 2022, 421(1):113373]	PubMed: 36183781

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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