受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C18H13BrN2O4S2 |
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分子量 | 465.34 | CAS No. | 432001-69-9 | ||||
Solubility (25°C)* | 体外 | DMSO | 93 mg/mL (199.85 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. |
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in vitro | Skp2 inhibitor C1 treatment of MCF-7 breast cancer cells lines does not increase, but rather decrease the percentage of cells in G1 while increasing the G2/M population[1]. |
細胞アッセイ | 細胞株 | 501 Mel cells |
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濃度 | 10 μM | |
反応時間 | 16 h | |
実験の流れ | 501 Mel cell lines are pretreated with each inhibitor (10 μM) or 0.1% DMSO (vehicle) for 16 h. Cycloheximide half-life is examined. |
SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis [ The Journal of Clinical Investigation, 2022-, -Volume 132, Issue 24] | PubMed: None |
SCF-SKP2 E3 ubiquitin ligase links mTORC1-ER stress-ISR with YAP activation in murine renal cystogenesis [ J Clin Invest, 2022, e153943] | PubMed: 36326820 |
Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis [ Curr Biol, 2022, 32(19):4314-4324.e7] | PubMed: 36007528 |
Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch [ Pharmaceuticals (Basel), 2022, 15(2)241] | PubMed: 35215353 |
Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer [ Cancer Discov, 2021, candisc.0209.2021] | PubMed: 34282029 |
Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer [ Cancer Discov, 2021, 11(12):3158-3177] | PubMed: 34282029 |
S-phase kinase-associated protein-2 (Skp2) promotes nucleus pulposus cell proliferation by inhibition of p27 in attenuating intervertebral disc degeneration [ Eur Rev Med Pharmacol Sci, 2020, 24(6):2802-2810] | PubMed: 32271397 |
SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27. [ Onco Targets Ther, 2019, 12:4297-4308] | PubMed: 31213847 |
Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis. [ Braz J Med Biol Res, 2019, 52(5):e8412] | PubMed: 31038581 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。