Sodium Houttuyfonate

製品コードS3801 バッチS380101

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C14H27O5S.Na
分子量 330.42 CAS No. 1847-58-1
Solubility (25°C)* 体外 DMSO Insoluble
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
in vitro Treatment with sodium houttuyfonate results in an increase in the expression of c-Fos protein in macrophages, while the phosphorylation level of extracellular signal-related kinase 1/2 (ERK1/2) is not affected by the treatment[2].
in vivo Sodium houttuyfonate has been shown to protect against cationized bovine serum albumin (C-BSA)-induced glomerulonephritis in BALB/C mice through the suppression of the urine protein, morphological character and monocyte chemotactic protein 1 (MCP-1). In addition, sodium houttuyfonate treatment has been shown to induce a respiratory burst and to increase the concentration of free calcium in macrophages, as well as increase IL-2 within T-cells. Sodium houttuyfonate in the serum, stomach and intestine can be detected immediately by GC at 0.5 h. The concentration of sodium houttuyfonate in the stomach gradually increases from 0.5–2 h, but is drastically reduced at 4 h. Furthermore, the concentration in the serum and intestine at 1–4 h decreases in a time-dependent manner, indicating that sodium houttuyfonate can be quickly absorbed into the circulatory system and intestine and might be quickly distributed to other organs, such as trachea, lung, brain, heart and kidney[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 synovial cells
濃度 25, 50, 100, 200 μg/ml
反応時間 seven days
実験の流れ The primary cells are equally divided into five groups as follows: the control group (group 1), cells treated with 25 μg/ml sodium houttuyfonate (group 2), 50 μg/ml sodium houttuyfonate (group 3), 100 μg/ml sodium houttuyfonate (group 4) and 200 μg/ml sodium houttuyfonate (group 5). Group 1 is administered an equivalent amount of normal saline (NS), whilst groups 2 to 5 are treated with corresponding amounts of sodium houttuyfonate. NS and sodium houttuyfonate are administered daily for 7 days by transfer pipette. Following the final administration, the five groups of synovial cells are measured using an MTT assay for analysis of the growth inhibitory rate of SH on synovial proliferation.
動物実験 動物モデル Male KM mice
投薬量 100 mg/kg
投与方法 orally administrated

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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