Sodium Lauryl Sulfoacetate

製品コードS3801 バッチS380102

印刷

化学情報

Synonyms

Lathanol

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₄H₂₇O₅S.Na

分子量

330.42

CAS No.

1847-58-1

Solubility (25°C)*

体外

DMSO

2 mg/mL (6.05 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Sodium Lauryl Sulfoacetate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
in vitro	Treatment with Sodium Lauryl Sulfoacetate results in an increase in the expression of c-Fos protein in macrophages, while the phosphorylation level of extracellular signal-related kinase 1/2 (ERK1/2) is not affected by this compound^[2].
in vivo	Sodium Lauryl Sulfoacetate has been shown to protect against cationized bovine serum albumin (C-BSA)-induced glomerulonephritis in BALB/C mice through the suppression of the urine protein, morphological character and monocyte chemotactic protein 1 (MCP-1). In addition, this compound treatment has been shown to induce a respiratory burst and to increase the concentration of free calcium in macrophages, as well as increase IL-2 within T-cells. This chemical in the serum, stomach and intestine can be detected immediately by GC at 0.5 h. The concentration of this compound in the stomach gradually increases from 0.5–2 h, but is drastically reduced at 4 h. Furthermore, the concentration in the serum and intestine at 1–4 h decreases in a time-dependent manner, indicating that it can be quickly absorbed into the circulatory system and intestine and might be quickly distributed to other organs, such as trachea, lung, brain, heart and kidney^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	synovial cells
	濃度	25, 50, 100, 200 μg/ml
	反応時間	seven days
	実験の流れ	The primary cells are equally divided into five groups as follows: the control group (group 1), cells treated with 25 μg/ml Sodium Lauryl Sulfoacetate (group 2), 50 μg/ml this compound (group 3), 100 μg/ml this compound (group 4) and 200 μg/ml this compound (group 5). Group 1 is administered an equivalent amount of normal saline (NS), whilst groups 2 to 5 are treated with corresponding amounts of this chemical. NS and this chemical are administered daily for 7 days by transfer pipette. Following the final administration, the five groups of synovial cells are measured using an MTT assay for analysis of the growth inhibitory rate of SH on synovial proliferation.
動物実験	動物モデル	Male KM mice
	投薬量	100 mg/kg
	投与方法	orally administrated

参考

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043587/
https://pubmed.ncbi.nlm.nih.gov/25514406/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。