Solanesol (Nonaisoprenol)

製品コードS2360 バッチS236001

印刷

化学情報

Synonyms

Nonaisoprenol, Betulanonaprenol

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₄₅H₇₄O

分子量

631.07

CAS No.

13190-97-1

Solubility (25°C)*

体外

DMSO

25 mg/mL (39.61 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Solanesol (Nonaisoprenol, Betulanonaprenol)は、FAKに対して阻害活性を持つ長鎖ポリイソプレノイドアルコール化合物です。主にタバコ、トマト、ジャガイモ、ナス、ピーマンなどのナス科作物に蓄積します。
in vitro	Solanesol (Nonaisoprenol) is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. This compound binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK). It upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. It also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects.

製品説明

Solanesol (Nonaisoprenol, Betulanonaprenol)は、FAKに対して阻害活性を持つ長鎖ポリイソプレノイドアルコール化合物です。主にタバコ、トマト、ジャガイモ、ナス、ピーマンなどのナス科作物に蓄積します。

in vitro

Solanesol (Nonaisoprenol) is widely used as an intermediate for the synthesis of ubiquinone drugs, such as coenzyme Q10 and vitamin K2 as well as Vitamin K and Vitamin E. It is known to possess activities like antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and anti-ulcer activities. This compound binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK). It upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction. It also inhibits LDH, AST, MDA and ROS level, but increases the GSH level and promotes tBHQ-mediated protective effects.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	normal human hepatic cell L02
	濃度	10, 50, 100, 250, 500, 1000 μM
	反応時間	12 h
	実験の流れ	Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 10⁴ cells/well) 24 h before treatment with various concentrations of solanesol (Nonaisoprenol). The cells are then incubated with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, they are detected under a Microplate Reader to measure the absorbance at 570 nm.
動物実験	動物モデル	Male albino rats
	投薬量	0.2 g of gel containing solanesol (1 % w/v)
	投与方法	applied to the plantar surface of the right hind paw by gently rubbing with the index finger

参考

https://www.biorxiv.org/content/early/2016/11/09/086660
https://pubmed.ncbi.nlm.nih.gov/25645596/
http://ukaazpublications.com/attached/publications/v6n1_Article%20-%2019_1.pdf

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。