Spiramycin

製品コードS4082 バッチS408201

化学情報

	Synonyms	Formacidine	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₄₃H₇₄N₂O₁₄
	分子量	843.05	CAS No.	8025-81-8
Solubility (25°C)*	体外	DMSO	157 mg/mL (186.22 mM)
		Ethanol	157 mg/mL (186.22 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
in vitro	Spiramycin reduces the hygromycin A protections of nucleotides in 23 S rRNA. ^[1] Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. Spiramycin acts primarily by stimulating the dissociation of peptidyl-tRNA from ribosomes during translocation. ^[2] Spiramycin at doses sufficient to inhibit protein synthesis in wild-type cells but not sufficient to kill either mutant or wild-type cells at the permissive temperature (30 degrees C). Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. ^[3] Spiramycin shows dose-related inhibition of the proliferative response of PHA and PWM stimulated human mononuclear leucocytes (MNL). Spiramycin also induces a decrease in tritiated uridine (3H-UdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle. ^[4] Spiramycin and, to a lesser extent, erythromycin increases total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide. ^[5] Spiramycin shows good antimicrobial activity against species of Prevotella, Eubacterium, Peptostreptococcus, Bacteroides and Porphyromonas, and the effect is enhanced by the addition of Metronidazole. ^[6]

製品説明

Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).

in vitro

Spiramycin reduces the hygromycin A protections of nucleotides in 23 S rRNA. ^[1] Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. Spiramycin acts primarily by stimulating the dissociation of peptidyl-tRNA from ribosomes during translocation. ^[2] Spiramycin at doses sufficient to inhibit protein synthesis in wild-type cells but not sufficient to kill either mutant or wild-type cells at the permissive temperature (30 degrees C). Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. ^[3] Spiramycin shows dose-related inhibition of the proliferative response of PHA and PWM stimulated human mononuclear leucocytes (MNL). Spiramycin also induces a decrease in tritiated uridine (3H-UdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle. ^[4] Spiramycin and, to a lesser extent, erythromycin increases total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide. ^[5] Spiramycin shows good antimicrobial activity against species of Prevotella, Eubacterium, Peptostreptococcus, Bacteroides and Porphyromonas, and the effect is enhanced by the addition of Metronidazole. ^[6]

プロトコル(参考用のみ)

参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Solution conformations explain the chameleonic behaviour of macrocyclic drugs. [ Chemistry, 2020, 10.1002/chem.201905599]	PubMed: 32027758

Solution conformations explain the chameleonic behaviour of macrocyclic drugs. [ Chemistry, 2020, 10.1002/chem.201905599]

PubMed: 32027758

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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