SR-717 lithium

製品コードS0853 バッチS085302

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₅H₈F₂LiN₅O₃

分子量

351.19

CAS No.

2375421-09-1

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

35 mg/mL (99.66 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 10%Tween80 2 85%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.000mg/ml (8.54mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 100 μL of Tween80, mix evenly to clarify; then continue to add 850 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
in vitro	SR-717 induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.^[1]
in vivo	SR-717 ( intraperitoneally for 7 days) displays antitumor activity in WT or Sting^gt/gt mice; promots the activation of CD8⁺ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	ISG-THP1 STING KO cell lines
	濃度	3.8 μM
	反応時間	4 h
	実験の流れ	"Western blot analyses the impact of SR-717 delivery (3.8 mM) on PD-L1 expression in WT THP1 or ISG-THP1 STING KO (STING KO) cells."
動物実験	動物モデル	Sting^gt/gt mice
	投薬量	30 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/32820126/
https://pubmed.ncbi.nlm.nih.gov/32820126/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists [ Nat Commun, 2025, 16(1):3440]	PubMed: 40216780
Targeted Delivery of STING Agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive Cancers [ Pharmaceutics, 2024, 16(9)1216]	PubMed: 39339252
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy [ Mol Neurobiol, 2022, 59(11):7006-7024]	PubMed: 36070120
Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats [ J Inflamm Res, 2022, 15:5103-5119]	PubMed: 36091334
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection [ Signal Transduct Target Ther, 2021, 6(1):382]	PubMed: 34732709

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。