STAT5-IN-1

製品コードS6784 バッチS678405

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₆H₁₁N₃O₃

分子量

293.28

CAS No.

285986-31-4

Solubility (25°C)*

体外

DMSO

20 mg/mL (68.19 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.
in vitro	STAT5-IN-1, the STAT5 phosphorylation specific inhibitor, selectively blocks the STAT5 signaling and decreases the percentage of CD4+CD25+Foxp3+ Tregs after SEC2 stimulation on murine splenocytes.^[2]
in vivo	STAT5-IN-1, a STAT5 inhibitor, significantly attenuates atherosclerosis in ApoE^-/- mice induced by HFD via decreasing inflammation.^[3]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	murine splenocytes
	濃度	0.47 mM
	反応時間	3 days
	実験の流れ	Fresh murine splenocytes seeded in 24-well flat-bottom plates are treated with each inhibitor at final concentrations of 10 μM LY294002, 10 mM Trigonelline, 0.47 mM STAT5-IN-1, 50 μM SB431542, and 1 μM SIS3, or treated with 10 μg/mL anti-IL-2 neutralizing antibody, respectively, then cells are stimulated with 10⁴ ng/mL SEC2 for 3 days in a humidified incubator at 37 ℃ with 5% CO₂.
動物実験	動物モデル	ApoE^-/- mice
	投薬量	10 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/18247434/
https://pubmed.ncbi.nlm.nih.gov/34560552/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014372/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Reciprocal regulation of MMP-28 and EGFR is required for sustaining proliferative signaling in PDAC [ J Exp Clin Cancer Res, 2025, 44(1):68]	PubMed: 39994761
Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis [ Sci Adv, 2025, 11(35):eadw9952]	PubMed: 40864703
Sustained AhR activity programs memory fate of early effector CD8+ T cells [ Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121]	PubMed: 38437537
Macrophage re-programming by JAK inhibitors relies on MAFB [ Cell Mol Life Sci, 2024, 81(1):152]	PubMed: 38528207
hFcγRIIa: a double-edged sword in osteoclastogenesis and bone balance in transgenic mice [ Front Immunol, 2024, 15:1425670]	PubMed: 39281679
Hedgehog receptors exert immune-surveillance roles in the epidermis across species [ Cell Rep, 2023, 42(8):112929]	PubMed: 37527037
CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis [ Front Immunol, 2023, 14:1078958]	PubMed: 37025992
GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis [ Front Immunol, 2023, 10.3389/fimmu.2023.1165306]	PubMed: 37920458
Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice [ Nutrients, 2023, 15(2)376]	PubMed: 36678247
Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet [ Int J Mol Sci, 2023, 24(18)13878]	PubMed: 37762180

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。