STM2457

製品コードS9870 バッチS987002

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₅H₂₈N₆O₂
	分子量	444.53	CAS No.	2499663-01-1
Solubility (25°C)*	体外	DMSO	89 mg/mL (200.21 mM)
		Ethanol	89 mg/mL (200.21 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.
in vitro	This compound has a highly efficient and selective catalytic inhibition on RNA methyltransferase METTL3, causing gene-expression defects consistent with an effect on the mRNA translational efficiency of m⁶A substrates.^[1]
in vivo	STM2457 prevents acute myeloid leukaemia (AML) expansion and reduces the number of key leukaemia stem cells in vivo.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	MOLM-13 cells
	濃度	0.1, 1, 5 and 10 μM
	反応時間	--
	実験の流れ	Western blot analysis
動物実験	動物モデル	AML PDX-1 mice (NPM1c cells), AML PDX-2 mice (MLL-AF6 cells), AML PDX-3 mice (MLL-AF10)
	投薬量	50 mg/kg
	投与方法	--

参考

https://pubmed.ncbi.nlm.nih.gov/33902106/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Subcellular level spatial transcriptomics with PHOTON [ Nat Commun, 2025, 16(1):4457]	PubMed: 40368943
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation [ Cell Rep, 2025, S2211-1247(25)01101-5]	PubMed: 41015030
METTL3 depletion blocks vesicular stomatitis virus replication in pancreatic cancer cells through the establishment of an intrinsic antiviral state [ J Virol, 2025, e0228424.]	PubMed: 40214229
METTL3 contributes to osimertinib resistance in non-small cell lung cancer cell lines by regulating CDC25A and AURKB mRNA stability [ Cell Signal, 2025, 136:112156]	PubMed: 41043761
The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops [ BMC Genomics, 2025, 26(1):223]	PubMed: 40050716
METTL3-mediated m 6A modification of pri-miRNA-31 promotes hypertrophic scar progression [ Acta Biochim Biophys Sin (Shanghai), 2025, 10.3724/abbs.2025033]	PubMed: 40109092
ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency [ Nat Commun, 2024, 15(1):8539]	PubMed: 39358345
METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer [ J Immunother Cancer, 2024, 12(12)e009865]	PubMed: 39653551
Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity [ Cell Rep, 2024, 43(2):113796]	PubMed: 38367240
N6-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing [ Cell Mol Biol Lett, 2024, 29(1):106]	PubMed: 39095708

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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