Streptozotocin (STZ)

製品コードS1312 バッチS131218

化学情報

	Synonyms	NSC-85998, Streptozocin, U 9889,STZ	Storage (From the date of receipt)	3 years -20°C(in the dark) powder
	化学式	C₈H₁₅N₃O₇
	分子量	265.22	CAS No.	18883-66-4
Solubility (25°C)*	体外	DMSO	53 mg/mL (199.83 mM)
		Water	53 mg/mL (199.83 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Streptozotocin (STZ) can be used to induce animal models of Diabetes Mellitus. Solutions are unstable and should be fresh-prepared.
in vitro	Streptozotocin (STZ) directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Free radicals are involved in the production of DNA and chromosome damage by this compound. ^[1] It is toxic to pancreatic beta cell. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. At 30 mM, it causes the cells to undergo necrosis (22%) as well as apoptosis (17%). ^[2]
in vivo	Streptozotocin (STZ) is often used to induce diabetes mellitus in experimental animals. It is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Injection of this compound (60 mg/kg) for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. It (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. ^[3] This compound is found to be carcinogenic in rats, mice and hamster. A single administration is able to induce tumors in kidney, liver, lung, pancreas, uterine and liver tumors in hamster. Intraperitoneally injected with it (100-150 mg/kg) for normotensive Wistar Kyoto rats (WKY) for 12 months induces carcinogenesis with tumors incidence of 70% in liver, 20% in kidney and 10% in liver and kidney. ^[4]

製品説明

STZ (Streptozotocin) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Streptozotocin (STZ) can be used to induce animal models of Diabetes Mellitus. Solutions are unstable and should be fresh-prepared.

in vitro

Streptozotocin (STZ) directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Free radicals are involved in the production of DNA and chromosome damage by this compound. ^[1]

It is toxic to pancreatic beta cell. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. At 30 mM, it causes the cells to undergo necrosis (22%) as well as apoptosis (17%). ^[2]

in vivo

Streptozotocin (STZ) is often used to induce diabetes mellitus in experimental animals. It is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Injection of this compound (60 mg/kg) for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. It (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. ^[3]

This compound is found to be carcinogenic in rats, mice and hamster. A single administration is able to induce tumors in kidney, liver, lung, pancreas, uterine and liver tumors in hamster. Intraperitoneally injected with it (100-150 mg/kg) for normotensive Wistar Kyoto rats (WKY) for 12 months induces carcinogenesis with tumors incidence of 70% in liver, 20% in kidney and 10% in liver and kidney. ^[4]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	INS-1 cells
	濃度	15 mm
	反応時間	1 h
	実験の流れ	Following exposure to 15 mM Streptozotocin (STZ) for 1 hr, cells underwent a 24 hrs recovery period.
動物実験	動物モデル	Male Holtzman rats
	投薬量	50, 65, & 100 mg/kg
	投与方法	i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/12464347/
https://pubmed.ncbi.nlm.nih.gov/8876977/
https://pubmed.ncbi.nlm.nih.gov/6015682/

https://pubmed.ncbi.nlm.nih.gov/2532796/
https://pubmed.ncbi.nlm.nih.gov/22330251/
https://pubmed.ncbi.nlm.nih.gov/27060530/

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カスタマーフィードバック

: , , Pharmacol Rep, 2017, 69(2):358-364

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation [ Int Immunopharmacol, 2025, 167:115682]	PubMed: 41110178
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Transient but not chronic hyperglycemia accelerates ocular glymphatic transport [ Fluids Barriers CNS, 2024, 21(1):26]	PubMed: 38475818
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis [ CNS Neurosci Ther, 2024, 30(8):e14913]	PubMed: 39123294

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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