Super-TDU

製品コードS8554 バッチS855402

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₃₇H₃₇₀N₆₆O₆₉S
	分子量	5279.94	CAS No.	1599441-71-0
Solubility (25°C)*	体外	Water	100 mg/mL (18.93 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
in vitro	Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, this compound downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. It significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of this chemical in inhibiting tumor cell growth. It may specifically target tumor cells with an elevated YAP/VGLL4 ratio^[1].
in vivo	Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HCT116 and SW480 cells
	濃度	0-320 ng/ml
	反応時間	72 h
	実験の流れ	Cells are transfected with the indicated plasmids. An ATP-based cell viability assay is used for detecting cell proliferation. The ATP content is measured. Briefly, 100 μl of assay reagent is added to the wells, and mixed for 2 min at room temperature. After 10 min, intracellular ATP content is measured using a multilabel luminescence counter. Cell viability is calculated.
動物実験	動物モデル	BALB/cA nu/nu mice
	投薬量	50 or 500 μg/kg
	投与方法	tail vein injection

参考

https://pubmed.ncbi.nlm.nih.gov/24525233/
https://pubmed.ncbi.nlm.nih.gov/28051067/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Involvement of lysophosphatidic acid-LPA1-YAP signaling in healthy and pathological FAPs migration [ Matrix Biol, 2024, S0945-053X(24)00107-0]	PubMed: 39153517
YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis [ Gut Microbes, 2023, 15(1):2192501]	PubMed: 36959122
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway [ Cell Death Discov, 2023, 9(1):424]	PubMed: 38001078
CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation [ Nat Commun, 2022, 13(1):3117]	PubMed: 35660741
Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2 [ JCI Insight, 2022, 7(14)e158207]	PubMed: 35708907
Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state [ Int J Mol Med, 2022, 49(6)84]	PubMed: 35514314
Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers [ Exp Dermatol, 2022, 31(10):1477-1499]	PubMed: 35913427
ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma [ J Exp Clin Cancer Res, 2021, 40(1):23]	PubMed: 33413564
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060]	PubMed: 34805150
Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway [ Front Cell Dev Biol, 2021, 9:741060]	PubMed: 34805150

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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