Swertiamarin

製品コードS3927 バッチS392701

印刷

化学情報

Synonyms

Swertiamaroside

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₆H₂₂O₁₀

分子量

374.34

CAS No.

17388-39-5

Solubility (25°C)*

体外

DMSO

74 mg/mL (197.68 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Swertiamarin（スウェルティアマロシド）は、リンドウ科の植物に共通して見られるセコイリドイドで、抗炎症作用、抗がん作用、血糖降下作用、脂質降下作用を有しています。
in vivo	Pharmacokinetic analysis shows that Swertiamarin is absorbed very fast, with very short plasma half-life of 1.3 h, and is completely eliminated from systemic circulation after 4-5 h. This compound treatment has no significant effect on adipogenesis, or the mRNA expression of PPAR-g and GLUT-4; however, there is a significant increase in the mRNA expression of adiponectin. On treatment, it exerts an antiinflammatory effect on macrophages and neutrophils by suppressing the release of free radicals, iNOS expression, and proinflammatory cytokines. It acts as an anti-inflammatory agent by suppressing proinflammatory mediators (Th1) and inducing anti-inflammatory mediators (Th2). This chemical decreases serum cholesterol levels and reduces the oxidation of LDL. In addition, it has also shown to have the ability in increasing the HDL levels and reduction in the ratio of LDL/HDL cholesterol. It has shown to modulate 5-HT2 receptor and hypolipidemic potential in animal models of depression, diabetes and obesity.

製品説明

Swertiamarin（スウェルティアマロシド）は、リンドウ科の植物に共通して見られるセコイリドイドで、抗炎症作用、抗がん作用、血糖降下作用、脂質降下作用を有しています。

in vivo

Pharmacokinetic analysis shows that Swertiamarin is absorbed very fast, with very short plasma half-life of 1.3 h, and is completely eliminated from systemic circulation after 4-5 h. This compound treatment has no significant effect on adipogenesis, or the mRNA expression of PPAR-g and GLUT-4; however, there is a significant increase in the mRNA expression of adiponectin. On treatment, it exerts an antiinflammatory effect on macrophages and neutrophils by suppressing the release of free radicals, iNOS expression, and proinflammatory cytokines. It acts as an anti-inflammatory agent by suppressing proinflammatory mediators (Th1) and inducing anti-inflammatory mediators (Th2). This chemical decreases serum cholesterol levels and reduces the oxidation of LDL. In addition, it has also shown to have the ability in increasing the HDL levels and reduction in the ratio of LDL/HDL cholesterol. It has shown to modulate 5-HT2 receptor and hypolipidemic potential in animal models of depression, diabetes and obesity.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	3T3-L1 mouse pre-adipocytes
	濃度	100 mg/mL
	反応時間	10 days
	実験の流れ	The 3T3-L1 mouse pre-adipocytes are cultured (37℃; 5% CO2) in DMEM (25mM glucose), containing 10% calf serum, 100 U/mL penicillin and 100 μg/mL streptomycin, until confluent. Two days post-confluency, media is replaced with DMEM, 10% (v/v) fetal bovine serum (FBS), insulin (10 μg/mL), dexamethasone (0.25 mM) and isobutyl-1-methylxanthine (0.5mM) with or without 100 μg/mL swertiamarin or gentianine. After 48 h, the medium is changed to DMEM containing 10% FBS and 10 μg/mL insulin along with the treatment. the medium is replaced every 48 h till day 10. This compound is dissolved in media while gentianine is dissolved in DMSO, thus there are two controls; cells without any treatment (NC), and cells treated with DMSO (0.05%). On the 10^th day, fully differentiated adipocytes are used for Oil red O staining, intracellular triglycerides accumulation andmRNA expressions of PPAR-g, GLUT-4 and adiponectin.
動物実験	動物モデル	Swiss albino mice
	投薬量	2, 5, and 10 mg/kg b.w.
	投与方法	orally

参考

https://pubmed.ncbi.nlm.nih.gov/22718571/
https://pubmed.ncbi.nlm.nih.gov/27780133/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Swertiamarin protects neuronal cells from oxygen glucose deprivation/reoxygenation via TLR4/PARP1/NF-κB pathway [ Pharmazie, 2019, 74(8):481-484]	PubMed: 31526441

Swertiamarin protects neuronal cells from oxygen glucose deprivation/reoxygenation via TLR4/PARP1/NF-κB pathway [ Pharmazie, 2019, 74(8):481-484]

PubMed: 31526441

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。