Taurolidine

製品コードS4885 バッチS488501

印刷

化学情報

Synonyms

Taurolin, Tauroline, Tauroflex

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₇H₁₆N₄O₄S₂

分子量

284.36

CAS No.

19388-87-5

Solubility (25°C)*

体外

DMSO

56 mg/mL (196.93 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Taurolidine（タウロリン、タウロライン、タウロフレックス）は、抗菌作用、抗凝固作用、および潜在的な血管新生阻害作用を持つ合成広域抗生物質です。
in vitro	Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro. This compound possesses antineoplastic activity. The antiproliferative IC50 of this chemical is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to this agent induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts. It causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis.
in vivo	In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals. The i.p. administration of this compound effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	a rat metastatic colorectal tumor cell line (DHD/K12/TRb)
	濃度	5, 10, 15, 25 mg/ml
	反応時間	14 h
	実験の流れ	DHD/K12/TRb cells (1×10^{5^{cells/ml) are cultured in 24-well plates and incubated for 6 hours at 37°C in humidified 5% CO2 conditions to allow the cells to adhere. Culture medium is then removed and fresh culture medium alone (control) or culture medium with 5, 10, 15, and 25 mg/ml of Taurolidine is added. Cells are then incubated at 37°C in humidified 5% CO2 conditions for a further 14 hours followed by addition of 10 ml of BrdU labeling solution.}}
動物実験	動物モデル	Adult male syngenic BD IX rats, aged 8-10 weeks
	投薬量	100 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/11034247/
http://cancerres.aacrjournals.org/content/61/18/6816
https://pubmed.ncbi.nlm.nih.gov/15569998/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271

Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]

PubMed: 39319271

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。