Tauroursodeoxycholic Acid (TUDCA)

製品コードS3654 バッチS365402

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C26H45NO6S
分子量 499.70 CAS No. 14605-22-2
Solubility (25°C)* 体外 DMSO 99 mg/mL (198.11 mM)
Ethanol 99 mg/mL (198.11 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) that acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).
in vitro Tauroursodeoxycholic acid (TUDCA) is an endogenous hydrophilic tertiary bile acid produced in humans at a low level. In ER stress conditions, treatment with this compound reduces the activation of ER stress-associated proteins, including GRP78, PERK, eIF2α, ATF4, IRE1α, JNK, p38, and CHOP, and inhibits the dissociation between GRP78 and PERK, resulting in reduced ER stress-mediated cell death. It also increases PrPC (Cellular prion protein) expression. TUDCA regulates stem cell differentiation into various lineages such as adipogenic and osteogenic lineages. It attenuates ER stress, prevents unfolded protein response dysfunction, and stabilizes mitochondria. Under ER stress, treatment with this compound significantly increases the expression of BCL-2 and significantly decreases the expression of Bax, cleaved caspase-3, and cleaved PARP-1, compared with that of untreated cells[1].
in vivo Tauroursodeoxycholic Acid (TUDCA) is effective for treating cholestatic liver diseases and also has an ameliorating effect on several diseases, including neurodegenerative diseases, osteoarthritis, vascular diseases, and diabetes. In a murine hindlimb ischemia model, TUDCA-treated mesenchymal stem cells (MSCs) transplantation augments the blood perfusion ratio, vessel formation, and transplanted cell survival more than untreated MSC transplantation does. Augmented functional recovery following MSC transplantation is blocked by PrPC downregulation[1]. Several studies in animals have shown that this compound, an endogenous ambiphilic bile acid, can inhibit unfolded protein response dysfunction and ameliorate ER stress. Its administration attenuates HDM-induced ER stress, airway inflammation, mucus metaplasia, airway remodeling, and methacholine-induced AHR[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Mesenchymal stem cells (MSCs)
濃度 100 μM
反応時間 30 min
実験の流れ

MSCs are washed twice with phosphate buffer saline (PBS), and fresh α-MEM supplemented with 10% FBS is added. To investigate the apoptosis signaling pathway, MSCs are pretreated with Tauroursodeoxycholic Acid (TUDCA) (100 μM) at 37 °C for 30 min and then treated with H2O2 (200 μM) for various times (0, 2, 4, 6, or 8 h). To assess another cell signaling pathway, MSCs are treated with an Akt inhibitor (10−6 M) for 30 min at 37 °C before treatment with this compound.
動物実験 動物モデル House dust mite-induced allergic airway disease mouse model (background: C57BL/6 NJ mice)
投薬量 0.5, 1, and 5 mg/kg body wt
投与方法 via the nasopharynx

参考

  • https://pubmed.ncbi.nlm.nih.gov/28004805/
  • https://pubmed.ncbi.nlm.nih.gov/27154200/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation [ Nat Commun, 2025, 16(1):50] PubMed: 39747098
CB-5083 and luteolin synergistically induce the apoptosis of bladder cancer cells via multiple mechanisms [ Toxicol Appl Pharmacol, 2025, 499:117333] PubMed: 40194745
GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress [ Cell Mol Life Sci, 2024, 81(1):299] PubMed: 39001944
Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring [ Cells, 2024, 13(3)214] PubMed: 38334606
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease [ iScience, 2023, 26(8):107312] PubMed: 37539032
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells [ Int J Mol Sci, 2023, 24(11)9640] PubMed: 37298591
Tauroursodeoxycholic Acid Supplementation in In Vitro Culture of Indicine Bovine Embryos: Molecular and Cellular Effects on the In Vitro Cryotolerance [ Int J Mol Sci, 2023, 24(18)14060] PubMed: 37762363
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells [ Int J Mol Sci, 2023, 24(11)9640] PubMed: 37298591
Tauroursodeoxycholic Acid Supplementation in In Vitro Culture of Indicine Bovine Embryos: Molecular and Cellular Effects on the In Vitro Cryotolerance [ Int J Mol Sci, 2023, 24(18)14060] PubMed: 37762363
Tauroursodeoxycholic acid protects Schwann cells from high glucose-induced cytotoxicity by targeting NLRP3 to regulate cell migration and pyroptosis [ Biotechnol Appl Biochem, 2023, 10.1002/bab.2518] PubMed: 37749820

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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