Tedizolid Phosphate

製品コードS4641 バッチS464101

印刷

化学情報

Synonyms

TR-701FA

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₇H₁₆FN₆O₆P

分子量

450.32

CAS No.

856867-55-5

Solubility (25°C)*

体外

DMSO

22 mg/mL (48.85 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.1mg/ml (2.44mM)	Taking the 1 mL working solution as an example, add 50 μL of 22 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.16mg/ml (0.36mM)	Taking the 1 mL working solution as an example, add 50 μL of 3.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tedizolid (TR-701FA)はオキサゾリジノン系抗生物質です。Tedizolid Phosphateは、活性化合物であるTedizolidのリン酸エステルプロドラッグです。
in vitro	Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA). Tedizolid is 4-fold more potent than linezolid against PRSP isolates in vitro.
in vivo	Tedizolid has excellent penetration into pulmonary epithelial lining fluid (ELF). Tedizolid phosphate administered to mice orally or intravenously is effective in vivo against systemic infection with PRSP isolates. Oral tedizolid phosphate is also effective in vivo against pneumonia induced with a PSSP strain.

プロトコル(参考用のみ)

動物実験	動物モデル	Male ICR mice
	投薬量	40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg
	投与方法	oral administration; i.v.

参考

https://pubmed.ncbi.nlm.nih.gov/22713339/
https://pubmed.ncbi.nlm.nih.gov/22687509/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Glycopeptide Antibiotics Impair Neutrophil Effector Functions [ International Archives of Allergy and Immunology, June 15, 2023, 932-948]	PubMed: 37321197
FDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect [ Journal of the Association for Research in Otolaryngology, 2024 Jun, 259-275]	PubMed: 38622383
FDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect [ Journal of the Association for Research in Otolaryngology, 2024, 259-275]	PubMed: 38622383
Glycopeptide Antibiotics Impair Neutrophil Effector Functions [ Int Arch Allergy Immunol, 2023, 184(9):932-948]	PubMed: 37321197
Machine Learning Identifies Ponatinib as a Potent Inhibitor of SARS-CoV2-induced Cytokine Storm [ Molecular Systems Biology, 2021, e10426]	PubMed: nan
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. [ Sci Transl Med, 2019, 11(516)]	PubMed: 31666400

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。