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Synonyms | 4-Hydroxy-TEMPO | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C9H18NO2 |
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分子量 | 172.24 | CAS No. | 2226-96-2 | |
Solubility (25°C)* | 体外 | DMSO | 35 mg/mL (203.2 mM) | |
Water | 35 mg/mL (203.2 mM) | |||
Ethanol | 35 mg/mL (203.2 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2. |
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in vitro | Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
in vivo | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
細胞アッセイ | 細胞株 | HL60 |
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濃度 | 0.05–1.6 mM | |
反応時間 | 96 h | |
実験の流れ | The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM). | |
動物実験 | 動物モデル | Male Wistar rats |
投薬量 | 30 mg/kg | |
投与方法 | bolus injection |
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy [ Cell Signal, 2023, 108:110712] | PubMed: 37196773 |
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [ J Ginseng Res, 2023, 47(1):144-154] | PubMed: 36644390 |
Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice [ Theranostics, 2021, 11(8):3796-3812] | PubMed: 33664862 |
Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction [ Redox Biol, 2021, 41:101886] | PubMed: 33592539 |
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma. [ Nat Commun, 2020, 23;11(1):433] | PubMed: 31974380 |
Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level [ J Bone Miner Res, 2020, 10.1002/jbmr.4215] | PubMed: 33289180 |
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy [Song S J Cell Physiol, 2019, 10.1002/jcp.28317] | PubMed: 30746698 |
Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells. [ Mediators Inflamm, 2019, 2019:7162976] | PubMed: 31316302 |
Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells. [ Toxicol Lett, 2019, 311:105-113] | PubMed: 31054874 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. [ Antioxid Redox Signal, 2017, 27(16):1347-1360] | PubMed: 28594240 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
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