Tetrahydropalmatine hydrochloride

製品コードS3854 バッチS385401

印刷

化学情報

Synonyms

Gindarine hydrochloride, 1-Tetrahydropalmitine HCl

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₁H₂₅NO₄.HCl

分子量

391.89

CAS No.

6024-85-7

Solubility (25°C)*

体外

DMSO

12 mg/mL (30.62 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) は、主にCorydalis属 (延胡索) のほか、Stephania rotundaなどの植物にも見られるイソキノリンアルカロイドです。これは強力な筋弛緩薬です。
in vitro	Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. It suppresses activation of the NF-kB signaling pathway, which results in regulation of IL-8 expression and specifically blocks the ERK1=2 and p38 MAPK signaling pathways. L-THP results in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP causes activation of caspase and resulted in apoptosis. l-THP possesses a blocking effect on dopamine D1 and D2 receptors and voltage-sensitive Ca2+ channels.
in vivo	l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	THP-1 cells
	濃度	0.2, 1, or 2 mM
	反応時間	24 h
	実験の流れ	Cell viability is examined by MTT assay. In brief, THP-1 cells are seeded at a density of 5×10⁴ cells/mL in 96-well plates. Each batch of cells includes a nontreated group as a control. Tetrahydropalmatine (0.2, 1, or 2 mM) and LPS (2 mg/mL) are then added to each well, after which the plates are incubated for 24 hours at 37℃ under 5% CO2. Next, MTT solutions (5 mg/mL) are added to each well, and the samples are then cultured for an additional 4 hours. The supernatant is then discarded, and 100 mL of dimethylsulfoxide is added to each well. Next, the optical density is read at 590 nm.
動物実験	動物モデル	Kunming mice
	投薬量	6.25, 12.5, and 18.75 mg/kg
	投与方法	administered intragastrically

参考

https://pubmed.ncbi.nlm.nih.gov/20828314/
https://pubmed.ncbi.nlm.nih.gov/28721806/
https://pubmed.ncbi.nlm.nih.gov/15842769/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain [ Mol Pain, 2021, 17:17448069211042117]	PubMed: 34505815

Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain [ Mol Pain, 2021, 17:17448069211042117]

PubMed: 34505815

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。