Tezacaftor (VX-661)

製品コードS7059 バッチS705904

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₆H₂₇F₃N₂O₆

分子量

520.5

CAS No.

1152311-62-0

Solubility (25°C)*

体外

DMSO

100 mg/mL (192.12 mM)

Ethanol

13 mg/mL (24.97 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
in vitro	VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Primary HBE cells
	濃度	5 μM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of drug for 24 h.
動物実験	動物モデル	Male FVB/n mice
	投薬量	2 mg/kg
	投与方法	i.p.

参考

http://investors.vrtx.com/releasedetail.cfm?releaseid=757597
https://pubmed.ncbi.nlm.nih.gov/33859562/
https://pubmed.ncbi.nlm.nih.gov/34587656/

カスタマーフィードバック

: Data from [Data independently produced by Sci Transl Med, 2014, 6(246), 246ra96]

: Data from [Data independently produced by , , J Cyst Fibros, 2018, doi:10.1016/j.jcf.2018.07.001]

: Data from [Data independently produced by , , NPJ Genom Med. 2017, 2:12]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis [ Nucleic Acids Res, 2025, 53(13)gkaf675]	PubMed: 40650978
Endometrium-derived organoids from cystic fibrosis patients and mice as new models to study disease-associated endometrial pathobiology [ Cell Mol Life Sci, 2025, 82(1):109]	PubMed: 40074868
CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation [ JCI Insight, 2025, 10(9)e191098]	PubMed: 40131363
Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease [ Stem Cell Res Ther, 2025, 16(1):573]	PubMed: 41116195
In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators [ Br J Pharmacol, 2025, 10.1111/bph.70176]	PubMed: 40831301
Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma [ Respirology, 2025, 30(1):25-40]	PubMed: 39358991
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators [ iScience, 2025, 28(3):111942]	PubMed: 40040803
Human Induced Lung Organoids: A Promising Tool for Cystic Fibrosis Drug Screening [ Int J Mol Sci, 2025, 26(2)437]	PubMed: 39859153
Molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the CFTR channel [ J Physiol, 2025, 603(19):5437-5453]	PubMed: 40785054
Inhibitors of the ubiquitin‑proteasome system rescue cellular levels and ion transport function of pathogenic pendrin (SLC26A4) protein variants [ Int J Mol Med, 2025, 55(5)69]	PubMed: 40052591

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。