Thiamine HCl (Vitamin B1)

製品コードS3211 バッチS321101

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₂ H₁₇N₄OS.HCl
	分子量	337.27	CAS No.	67-03-8
Solubility (25°C)*	体外	Water	68 mg/mL (201.61 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	チアミンまたはビタミンB1は水溶性のB群ビタミンであり、そのリン酸誘導体は多くの細胞プロセスに関与しています。
in vitro	Thiamine HCl (Vitamin B1) (50 mM), in addition to its nutritional value, induces systemic acquired resistance (SAR) in rice, tobacco, cucumber, and Arabidopsis. It also confers resistance to fungal, bacterial, and viral infections in treated rice, Arabidopsis (Arabidopsis thaliana), and vegetable crop plants. This compound induces the transient expression of pathogenesis-related (PR) genes in rice and other plants, and potentiates stronger and more rapid PR gene expression along with up-regulation of protein kinase C activity. At a concentration of 10 μM, it prevents acetaldehyde-induced inhibition of myocyte shortening in adult rat ventricular myocytes, effectively blunts the acetaldehyde-induced depression in ±dL/dt, and prevents acetaldehyde-induced shortening of time-to-peak shortening. Furthermore, it inhibits acetaldehyde-induced elevation in both protein carbonyl formation and caspase-3 activation in adult rat ventricular myocytes. Its uptake is energy- and temperature-dependent, pH-sensitive, Na+-independent, and saturable at both the nanomolar (apparent Km, 30 nM) and the micromolar (apparent Km, 1.72 mM) concentration ranges in ARPE-19 cells. Uptake of this compound is adaptively regulated by extracellular substrate level via transcriptionally mediated mechanisms that involve both hTHTR-1 and hTHTR-2 in ARPE-19 cells, and is also regulated by an intracellular Ca2+-calmodulin-mediated pathway. Thiamine-responsive megaloblastic anemia (TRMA) fibroblasts are rescued from death with 10 nM-30 nM of it (in the range of normal plasma thiamine concentrations). Normal fibroblasts exhibit saturable, high-affinity thiamine uptake (Km 400 nM-550 nM; Vmax 11 pmol/min/1×10⁶ cells), while TRMA fibroblasts lack detectable high-affinity uptake. At 30 nM, the rate of its uptake by TRMA fibroblasts is 10-fold less than that of wild-type, which explains the increased apoptosis of TRMA fibroblasts.
in vivo	Thiamine HCl (Vitamin B1) deficiency results in amyloid precursor protein immunoreactivity accumulated in swollen neurites within, or around lesions in rats, or in abnormal clusters in mice.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/15980201/
https://pubmed.ncbi.nlm.nih.gov/15304379/
https://pubmed.ncbi.nlm.nih.gov/17463047/

https://pubmed.ncbi.nlm.nih.gov/10074490/
https://pubmed.ncbi.nlm.nih.gov/9261840/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity [ Signal Transduct Target Ther, 2024, 9(1):86]	PubMed: 38584163
Maternal vitamin B1 is a determinant for the fate of primordial follicle formation in offspring [ Nat Commun, 2023, 10.1038/s41467-023-43261-8]	PubMed: 37973927

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。