受注:045-509-1970 |
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Synonyms | NSC 21548, Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C10H14N2O5 |
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分子量 | 242.23 | CAS No. | 50-89-5 | |
Solubility (25°C)* | 体外 | DMSO | 48 mg/mL (198.15 mM) | |
Water | 48 mg/mL (198.15 mM) | |||
Ethanol | 6 mg/mL (24.76 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. |
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in vitro | Thymidine (NSC 21548), a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose, pairs with adenine when DNA synthesis.[1] |
細胞アッセイ | 細胞株 | USP28-depleted MDA-MB-231 cells |
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濃度 | 4 mM | |
反応時間 | 18 h | |
実験の流れ | 72 hours after shRNA lentiviruses infection, MDA-MB-231 cells are treated with 4 mM Thymidine for 18 hours. Release and harvest cells at the time points of 0, 6 and 18 hours, and then determine the cell cycle distribution by FACS analysis. |
TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry [ Nat Commun, 2024, 15(1):2371] | PubMed: 38490996 |
IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer [ EMBO J, 2023, e110620.] | PubMed: 36637036 |
c-myc-mediated upregulation of NAT10 facilitates tumor development via cell cycle regulation in non-small cell lung cancer [ Med Oncol, 2022, 39(10):140] | PubMed: 35834140 |
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma [ Elife, 2021, 10e65234] | PubMed: 33983115 |
The Deubiquitinase USP28 Stabilizes Expression of RecQ Family Helicases and Maintains the Viability of Triple Negative Breast Cancer Cells [ J Biol Chem, 2021, S0021-9258(21)01252-7] | PubMed: 34822842 |
Resistance to platinum chemotherapy in lung adenocarcinoma is driven by a non-genetic, cell-cycle dependent mechanism [ bioRxiv, 2020, 10.1101/2020.11.26.400499] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。