TLR2-IN-C29

製品コードS6597 バッチS659701

印刷

化学情報

Synonyms

C29

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₆H₁₅NO₄

分子量

285.29

CAS No.

363600-92-4

Solubility (25°C)*

体外

DMSO

57 mg/mL (199.79 mM)

Ethanol

6 mg/mL (21.03 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling.
in vitro	TLR2-IN-C29 inhibites TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. This compound fails to inhibit signaling induced by other TLR agonists and TNF-α.^[2]
in vivo	TLR2-IN-C29 reduces significantly the growth of tumors in Clear cell Renal Cell (RCC) and Head and Neck Squamous Cell Carcinomas (HNSCC) xenograft mice.^[3]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	THP-1 cells, HEK-TLR2 cells, murine macrophages
	濃度	10 μM-150 μM
	反応時間	5 h
	実験の流れ	After transfection, cells are allowed to recover for 48 h and treated for 5 h with medium or stimuli in the presence/absence of this compound. Cells are lysed in a passive lysis buffer, and firefly luciferase and Renilla luciferase activities are measured using the Dual-Luciferase Reporter Assay System. Cytokine levels in culture supernatants are analyzed by Multiplex beads in the Cytokine Core Laboratory.
動物実験	動物モデル	Ectopic model of RCC (nude female mice beearing A498 cells), Ectopic model of HNSCC (nude female mice beearing 786-O cells)
	投薬量	50 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/25870276/
https://pubmed.ncbi.nlm.nih.gov/25870276/
https://pubmed.ncbi.nlm.nih.gov/31410218/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis [ Protein Cell, 2025, pwaf020]	PubMed: 39998389
α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson's disease [ J Neuroinflammation, 2025, 22(1):38]	PubMed: 39934862
Direct activation of Toll-like receptor 2 signaling stimulated by contact with the interfacial structures of chitin nanofibers [ Int J Biol Macromol, 2025, 284(Pt 2):138092]	PubMed: 39613079
Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2/NF-κB pathway [ Phytomedicine, 2025, 141:156705]	PubMed: 40215821
Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes [ EMBO Rep, 2025, 10.1038/s44319-025-00558-7]	PubMed: 40925957
Mitochondrial ROS-ER Stress Axis Governs IL-10 Production in Neutrophils and Regulates Inflammation in Murine Chlamydia pneumoniae Lung Infection [ Cells, 2025, 14(19)1523]	PubMed: 41090752
The immune response against cancer is modulated by stromal cell fibronectin [ Neoplasia, 2025, 67:101196]	PubMed: 40592236
Royal jelly fermented by honeybee queen (Apis mellifera)-derived Lactobacillus panisapium M1 enhances macrophage phagocytosis through the TLR2/MAPK/SR signaling pathway [ BMC Complement Med Ther, 2025, 25(1):222]	PubMed: 40604913
Pentatrichomonas hominis induces extracellular traps formation of macrophages via the TLR2/NADPH/PAD4 pathway [ Parasit Vectors, 2025, 18(1):248]	PubMed: 40598534
A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy [ Nat Commun, 2024, 15(1):10726]	PubMed: 39730328

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。