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Synonyms | C29 | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C16H15NO4 |
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分子量 | 285.29 | CAS No. | 363600-92-4 | ||||
Solubility (25°C)* | 体外 | DMSO | 57 mg/mL (199.79 mM) | ||||
Ethanol | 6 mg/mL (21.03 mM) | ||||||
Water | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling. |
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in vitro | TLR2-IN-C29 inhibites TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. TLR2-IN-C29 fails to inhibit signaling induced by other TLR agonists and TNF-α.[2] |
in vivo | TLR2-IN-C29 reduces significantly the growth of tumors in Clear cell Renal Cell (RCC) and Head and Neck Squamous Cell Carcinomas (HNSCC) xenograft mice.[3] |
細胞アッセイ | 細胞株 | THP-1 cells, HEK-TLR2 cells, murine macrophages |
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濃度 | 10 μM-150 μM | |
反応時間 | 5 h | |
実験の流れ | After transfection, cells are allowed to recover for 48 h and treated for 5 h with medium or stimuli in the presence/absence of C29. Cells are lysed in a passive lysis buffer, and firefly luciferase and Renilla luciferase activities are measured using the Dual-Luciferase Reporter Assay System. Cytokine levels in culture supernatants are analyzed by Multiplex beads in the Cytokine Core Laboratory. |
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動物実験 | 動物モデル | Ectopic model of RCC (nude female mice beearing A498 cells), Ectopic model of HNSCC (nude female mice beearing 786-O cells) |
投薬量 | 50 mg/kg | |
投与方法 | p.o. |
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression [ Cell Res, 2023, 33(8):585-603] | PubMed: 37337030 |
Dual RNA-Sequencing and Liquid Chromatography-Mass Spectrometry Unveil Specific Insights on the Pathogenicity of Trichophyton mentagrophytes Complex [ J Invest Dermatol, 2023, 143(3):470-479.e6] | PubMed: 38295003 |
Acrylamide induces the activation of BV2 microglial cells through TLR2/4-mediated LRRK2-NFATc2 signaling cascade [ Food Chem Toxicol, 2023, 176:113775] | PubMed: 37037409 |
Acrylamide induces the activation of BV2 microglial cells through TLR2/4-mediated LRRK2-NFATc2 signaling cascade [ Food Chem Toxicol, 2023, 176:113775] | PubMed: 37037409 |
Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung [ Nat Commun, 2022, 13(1):3321] | PubMed: 35680890 |
Distinct activities of Vδ1+ T-cells upon different cytomegalovirus reactivation status after haematopoietic transplantation [ Immunology, 2022, 167(3):368-383] | PubMed: 35795896 |
Structural characterization and immunomodulatory mechanisms of two novel glucans from Morchella importuna fruiting bodies [ Int J Biol Macromol, 2021, 183:145-157] | PubMed: 33878360 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。