Tocilizumab (anti-IL-6R)

製品コード：A2012         Batch: A201202

印刷

Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.

製品説明

CAS No. ‎375823-41-9
Formulation PBS buffer, pH 7.2
Isotype Human IgG1
Source CHO cells
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Purity 98.85%
Protein concentration 4.97mg/ml
Endotoxin Level ≤1 EU/mg

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss [ Cell Rep, 2025, 44(7):115953] PubMed: 40616843
Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritis [ Cell Rep, 2025, 44(2):115287] PubMed: 40009514
HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop [ Cell Biol Toxicol, 2025, 41(1):36] PubMed: 39873845
Cells in the Polyaneuploid Cancer Cell State Are Prometastatic [ Mol Cancer Res, 2025, 23(3):219-235] PubMed: 39656186
Targeting Fibroblast-Derived Interleukin 6: A Strategy to Overcome Epithelial-Mesenchymal Transition and Radioresistance in Head and Neck Cancer [ Cancers (Basel), 2025, 17(2)267] PubMed: 39858048
IL-6-Caspase 3 Axis Plays an Important Role in Enteritis Caused by Legionella pneumophila Pulmonary Infection [ Microorganisms, 2025, 13(2)313] PubMed: 40005679
Targeting RPE Senescence Via Suppressing IL-6/IL-6R Signaling for Treating Retinal Degenerative Diseases [ Invest Ophthalmol Vis Sci, 2025, 66(12):44] PubMed: 40970669
AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution [ Nature, 2024, 10.1038/s41586-024-08031-6] PubMed: 39385030
Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells [ Cell Rep Med, 2024, S2666-3791(24)00195-2] PubMed: 38670095
CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment [ J Exp Clin Cancer Res, 2024, 43(1):277] PubMed: 39358777

人間や獣医の診断であるか治療的な使用のためにでない。