受注:045-509-1970 |
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Synonyms | NSC609699,Nogitecan,SKFS 104864A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C23H23N3O5 |
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分子量 | 421.45 | CAS No. | 123948-87-8 | |
Solubility (25°C)* | 体外 | DMSO | 84 mg/mL (199.31 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. |
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in vitro | Topotecan exhibits inhibition of outgrowth of the highly invasive and migratory leader cells (LC) population, however, topotecan enrichs the LC subset 20% above the untreated control level.[2] |
in vivo | Topotecan (TPT), at least in part by inhibiting expression of Fli-1, significantly ameliorates lupus nephritis in NZBWF1 mice as effectively or better than cyclophosphamide (CYC).[3] |
細胞アッセイ | 細胞株 | LC-T2A-GFP lines |
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濃度 | 1 μM | |
反応時間 | 72 h | |
実験の流れ | LC-T2A-GFP lines are seeded at 1200 cells per well of a 384-well plate, adhered overnight, and treated with chemotherapeutics olaparib, rucaparib, paclitaxel, topotecan, carboplatin, cyclophosphamide, cisplatin, and doxorubicin at empirically determined clinically relevant doses (1 μM). Cells are maintained at 37 ℃ with 5% CO2 in treatment for 72 h. Four focal areas per replicate well were imaged using 4X magnification on a bright field. |
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動物実験 | 動物モデル | NZBWF1 female mice |
投薬量 | 0.03 mg/kg, 0.1 mg/kg, 0.3mg/kg | |
投与方法 | i.p. |
Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma [ Cell Rep Med, 2023, 4(6):101091] | PubMed: 37343516 |
Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer [ Braz J Med Biol Res, 2023, 55:e12206] | PubMed: 36629522 |
FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy [ Clin Transl Med, 2022, 12(5):e881] | PubMed: 35604033 |
Secreted HSP90α-LRP1 Signaling Promotes Tumor Metastasis and Chemoresistance in Pancreatic Cancer [ Int J Mol Sci, 2022, 23(10)5532] | PubMed: 35628341 |
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan [ Molecules, 2022, 27(11)3374] | PubMed: 35684313 |
Immunogenicity of small-cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition [ Cancer Med, 2022, 10.1002/cam4.5109] | PubMed: 35957613 |
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria [ Nat Commun, 2021, 12(1):5404] | PubMed: 34518526 |
Camptothecin and topotecan, inhibitors of transcription factor Fli-1 and topoisomerase, markedly ameliorate lupus nephritis in NZBWF1 mice and reduce the production of inflammatory mediators in human renal cells [ Arthritis Rheumatol, 2021, 10.1002/art.41685] | PubMed: 33559345 |
Chemoresistance is mediated by ovarian cancer leader cells in vitro [ J Exp Clin Cancer Res, 2021, 40(1):276] | PubMed: 34470672 |
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11 [ Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00817-y] | PubMed: 34893686 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。