Trifluoperazine

製品コードS5856 バッチS585601

印刷

化学情報

Synonyms

NSC-17474, RP-7623, SKF-5019

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₁H₂₄F₃N₃S

分子量

407.50

CAS No.

117-89-5

Solubility (25°C)*

体外

体内（毎回新しく調製した物を用意してください）

Clear solution

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

2.000mg/ml (4.91mM)

Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明	Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Potent and highly selective inhibition of selpercatinib towards UDP-glucuronosyltransferase 1A4 (UGT1A4) isoform [ Toxicol Appl Pharmacol, 2025, 500:117393]	PubMed: 40354983
A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors [ Glia, 2024, ]	PubMed: 39495090
Inhibition of human UDP-glucuronosyltransferase enzyme by entrectinib: Implications for drug-drug interactions [ Chem Biol Interact, 2024, 395:111023]	PubMed: 38677539
Avapritinib Carries the Risk of Drug Interaction via Inhibition of UDP-Glucuronyltransferase (UGT) 1A1 [ Curr Drug Metab, 2024, 25(3):197-204]	PubMed: 38803186
Inhibition of human UDP-glucuronosyltransferase enzyme by ripretinib: Implications for drug-drug interactions [ Toxicol Appl Pharmacol, 2023, 466:116490]	PubMed: 36963523
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization [ Cell Rep Methods, 2023, 3(10):100599]	PubMed: 37797618
In vitro effects of opicapone on activity of human UDP-glucuronosyltransferases isoforms [ Toxicol Lett, 2022, 367:3-8]	PubMed: 35810997
Comparison of the drug-drug interactions potential of ibrutinib and acalabrutinib via inhibition of UDP-glucuronosyltransferase [ Toxicol Appl Pharmacol, 2021, 424:115595]	PubMed: 34038714
In vitro inhibition of human UDP-glucuronosyltransferase (UGT) 1A1 by osimertinib, and prediction of in vivo drug-drug interactions [ Toxicol Lett, 2021, 348:10-17]	PubMed: 34044055
Inhibition of human UDP-glucuronosyltransferase enzyme by Dabrafenib: Implications for drug-drug interactions [ Biomed Chromatogr, 2021, e5205]	PubMed: 34192355

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。