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Synonyms | Yoshimilon, Kyurinett, Vastarel F | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C14H22N2O3.2HCl |
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分子量 | 339.26 | CAS No. | 13171-25-0 | |
Solubility (25°C)* | 体外 | DMSO | 67 mg/mL warmed with 50ºC water bath (197.48 mM) | |
Water | 67 mg/mL (197.48 mM) | |||
Ethanol | 1 mg/mL (2.94 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor. |
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in vitro | Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3]. |
in vivo | The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2]. |
細胞アッセイ | 細胞株 | human H9C2 cell line |
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濃度 | 10 μM | |
反応時間 | 48 h | |
実験の流れ | The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment. |
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動物実験 | 動物モデル | C57BL/6J, AMPK KD mice |
投薬量 | 0.5 mg/kg | |
投与方法 | tail vein injection |
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Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp [ mBio, 2023, e0291922.] | PubMed: 36779788 |
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752] | PubMed: 34783031 |
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752] | PubMed: 34783031 |
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury [ Inflamm Res, 2022, 10.1007/s00011-021-01530-6] | PubMed: 34993560 |
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335] | PubMed: 35910357 |
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335] | PubMed: 35910357 |
The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions. [ Cell Cycle, 2019, 18(5):596-604] | PubMed: 30724698 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。