Trimetazidine dihydrochloride

製品コードS4543 バッチS454303

印刷

化学情報

Synonyms

Yoshimilon, Kyurinett, Vastarel F

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₄H₂₂N₂O₃.2HCl

分子量

339.26

CAS No.

13171-25-0

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

68 mg/mL (200.43 mM)

Water

68 mg/mL (200.43 mM)

Ethanol

5 mg/mL (14.73 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution

saline

50.0mg/ml

Taking the 1 mL working solution as an example, add 50 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
in vitro	Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion^[3].
in vivo	The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	human H9C2 cell line
	濃度	10 μM
	反応時間	48 h
	実験の流れ	The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment.
動物実験	動物モデル	C57BL/6J, AMPK KD mice
	投薬量	0.5 mg/kg
	投与方法	tail vein injection

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp [ mBio, 2023, e0291922.]	PubMed: 36779788
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752]	PubMed: 34783031
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93A mice [ Br J Pharmacol, 2022, 179(8):1732-1752]	PubMed: 34783031
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury [ Inflamm Res, 2022, 10.1007/s00011-021-01530-6]	PubMed: 34993560
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335]	PubMed: 35910357
QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway [ Front Pharmacol, 2022, 13:918335]	PubMed: 35910357
The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions. [ Cell Cycle, 2019, 18(5):596-604]	PubMed: 30724698

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。