Tunicamycin

製品コードS7894 バッチS789401

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₃₇H₆₀N₄O₁₆

分子量

816.89

CAS No.

11089-65-9

Solubility (25°C)*

体外

DMSO

5 mg/mL (6.12 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5% DMSO 1 95% Corn oil	0.2mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	0.2mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis.

プロトコル(参考用のみ)

参考

[1] Hou H, et,al. Mol Cancer Ther. 2013 Dec;12(12):2874-84.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation [ Cell Discov, 2023, 9(1):92]	PubMed: 37679337
Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation [ Cell Discov, 2023, 9(1):92]	PubMed: 37679337
Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe2+ in Skin Repair Cells to Accelerate Diabetic Wound Healing [ Adv Sci (Weinh), 2023, 10(25):e2300414]	PubMed: 37387572
Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma [ Oral Oncol, 2023, 146:106562]	PubMed: 37666053
[ Radiat Environ Biophys, 2020, ]	PubMed: 32857208
Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation [ PLoS Pathog, 2018, 14(7):e1007208]	PubMed: 30052682
Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts [ J Cell Physiol, 2016, 231(5):1142-50]	PubMed: 26445298

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。