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Synonyms | ASC-40, FASN-IN-2 | Storage (From the date of receipt) |
3 years -20°C powder | ||||
化学式 | C27H29N5O |
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分子量 | 439.55 | CAS No. | 1399177-37-7 | ||||
Solubility (25°C)* | 体外 | DMSO | 88 mg/mL (200.2 mM) | ||||
Ethanol | 88 mg/mL (200.2 mM) | ||||||
Water | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Denifanstat (TVB-2640) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis. |
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in vitro | TVB-2640 markedly inhibits SARS-CoV-2 with EC50s of 4 nM. TVB-2640 could strikingly inhibit SARS-CoV-2 new variants with similar inhibitory effects on the early-lineage SARS-CoV-2 (USA-WA1/2020) virus.[2] |
in vivo | TVB-2640 shows significant in vivo antiviral activity and protects SARS-CoV-2-infected mice for survival.[2] |
細胞アッセイ | 細胞株 | HEK293T-hACE2, Caco-2, MEF-hACE2 cells |
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濃度 | 100 nM for HEK293T-hACE2 cells; 2 µM for NCI-H1355, NCI-1437 and Caco-2 cells; 1 µM for MEF-hACE2 cells | |
反応時間 | 16+24 h | |
実験の流れ | Indicated cells were pre-treated with TVB-2640 from 16 h before infection and then infected with SARS-CoV-2-mNG. Fluorescence images were acquired at 48 hpi. Hoechst 33342 was used for nuclear staining. Assessment of anti-SARS-CoV-2 ability of FAS inhibitors in multiple cell lines. Indicated cells were pre-treated with TVB-2640 and infected with SARS-CoV-2 for 24 h, after infection cells were collected for quantification of intracellular viral RNA by qPCR. |
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動物実験 | 動物モデル | K18-hACE2 transgenic mice infected by SARS-CoV-2 |
投薬量 | 8 mg kg-1 body weight | |
投与方法 | i.p. (Data sourced from selleck products) |
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Formate promotes invasion and metastasis in reliance on lipid metabolism [ Cell Rep, 2023, 42(9):113034] | PubMed: 37651228 |
FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma [ J Transl Med, 2023, 21(1):32] | PubMed: 36650542 |
Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancer [ Cancer Cell Int, 2023, 23(1):83] | PubMed: 37120513 |
The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer [ Front Oncol, 2022, 12:899987] | PubMed: 35898882 |
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication [ Nat Metab, 2021, 10.1038/s42255-021-00479-4] | PubMed: 34580494 |
Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies [ Cancer Metab, 2021, 9(1):31] | PubMed: 34399819 |
Molecular Response to PARP1 Inhibition in Ovarian Cancer Cells as Determined by Mass Spectrometry Based Proteomics [ bioRxiv, 2021, 10.1101/2021.03.12.435005] | PubMed: None |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。