Umbelliferone

製品コードS3675 バッチS367501

印刷

化学情報

Chemical Structure Synonyms 7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H6O3
分子量 162.14 CAS No. 93-35-6
Solubility (25°C)* 体外 DMSO 32 mg/mL (197.36 mM)
Ethanol 32 mg/mL (197.36 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.
in vitro Treatment of KB cells with Umbelliferone (UMB), prevents and reduces the cell proliferation with the IC50--200 μM as well as induces loss of cell viability, morphology change and internucleosomal DNA fragmentation in a concentration dependent manner. UMB induces apoptosis in KB cells in a dose dependent manner. UMB has the potential to increase oxidative DNA damage in KB cells through DNA tail formation significantly. UMB brings a dose-dependent elevation of reactive oxygen species (ROS), which is evidenced by the DCF fluorescence, alters the mitochondrial membrane potential in KB cells. UMB exhibits anticancer effect on KB cell line with the increased generation of intracellular ROS, triggers oxidative stress mediated depolarization of mitochondria, which contributes cell death via DNA damage as well as cell cycle arrest at G0/G1 phase. UMB protects alcoholic fatty liver, detoxify reactive aldehyde, radiation mediated cellular damage in human blood lymphocytes, immuno modulators and treat vascular lesions[1].
in vivo Treatment with umbelliferone (60 and 90 mg/kg) causes a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation are observed in mice treated with umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-γ, is found in bronchoalveolar lavage fluids of mice treated with umbelliferone. umbelliferone attenuates airway inflammation in a murine model of asthma[2]. Dietary administration of umbelliferone and esculetin significantly attenuates MPTP-induced neurotoxicity in the substantia nigra pars compacta but not striatum, as measured by tyrosine hydroxylase staining. Umbelliferone also prevents MPTP-dependent caspase 3 activation, an indicator of apoptosis, but does not inhibit monoamine oxidase activity[3].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 KB cells
濃度 0–500 μg/ml
反応時間 24 h
実験の流れ Cells are seeded in 6 or 12 well plates prior to the addition of UMB. The KB cells are incubates with UMB (0-500 μg/ml of KB cells) for 24 h.
動物実験 動物モデル BALB/c mice
投薬量 30, 60 and 90 mg/kg
投与方法 oral

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway [ Food Chem Toxicol, 2022, S0278-6915(22)00089-8] PubMed: 35278496

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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