Usnic acid

製品コードS4953 バッチS495301

化学情報

	Synonyms	Usniacin	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₈H₁₆O₇
	分子量	344.32	CAS No.	125-46-2
Solubility (25°C)*	体外	DMSO	4 mg/mL (11.61 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.
in vitro	Usnic acid inhibits cell growth involving G0/G1 phase cell cycle arrest and induces cell death via mitochondrial membrane depolarization and induction of apoptosis in human lung carcinoma cells. Usnic acid has shown activity againstmany cancer cells such as lung carcinoma cells, murine leukemia P388 and L1210 cells, colon carcinoma HT-29 and HCT-116 cells, breast adenocarcinoma MCF-7 cells, and cervix adenocarcinoma cells^[1]. Usnic acid also selectively inhibits the viability of human breast cancer MCF-7 cells in a concentration- and time-dependent manner, provoking the generation of reactive oxygen species (ROS), which triggers the mitochondrial/caspase apoptotic pathway in MCF-7 cells^[2].
in vivo	In an MCF-7 xenograft model, Usnic acid significantly suppresses the growth of tumors by inducing apoptosis in the tumor cells without overt toxic side effects^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	A549 cells
	濃度	25, 50, and 100 μM
	反応時間	24 and 48 h
	実験の流れ	Cells at a density of 1 × 10⁵ are seeded per 60-mm culture plate and treated with either DMSO or indicated concentrations of usnic acid for 24 and 48 h. After each treatment time, cells are harvested by brief trypsinization and then gently mixed with trypan blue and counted using hemocytometer.
動物実験	動物モデル	6- to 8-week-old female BALB/c nu/nu mice (subcutaneously injected with MCF-7 cells)
	投薬量	25, 50 or 100 mg/kg
	投与方法	i.p.

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。