VBIT-12

製品コードS8936 バッチS893601

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₂₅H₂₇N₃O₃

分子量

417.50

CAS No.

2089227-65-4

Solubility (25°C)*

体外

DMSO

83 mg/mL (198.8 mM)

Water

2 mg/mL (4.79 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	4.150mg/ml (9.94mM)	Taking the 1 mL working solution as an example, add 50 μL of 83 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.030mg/ml (2.47mM)	Taking the 1 mL working solution as an example, add 50 μL of 20.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.
in vitro	VBIT-12 directly interacts with purified VDAC1 and reduces its channel conductance. This compound interferes with VDAC1 oligomerization and thus with the pro-apoptotic action of VDAC1 when the levels of expression are abnormal, but have no effect on cells under physiological conditions.^[2]
in vivo	The effect of VBIT-12 on induction of startle habituation and prepulse inhibition (PPI) in animals is examined via novelty suppressed feeding test, sweet preference model of anhedonia and forced swim test (FST) model for despair. This compound interacts with the Voltage-Dependent Anion Channel (VDAC) and can be used for the treatment of central nervous system (CNS) disorders and diseases.^[1]

プロトコル(参考用のみ)

動物実験	動物モデル	male 129 SVE adult mice, male BALB/c mice aged 8 weeks
	投薬量	20 mg/kg
	投与方法	Oral gavage

参考

https://patents.google.com/patent/US20200000801A1
https://pubmed.ncbi.nlm.nih.gov/29551631/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation [ PLoS Pathog, 2025, 21(1):e1012872]	PubMed: 39804926
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage [ Heliyon, 2024, 10(1):e23426]	PubMed: 38173512
The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK-CRTCs/CREB-MITF pathway [ Exp Cell Res, 2024, 434(2):113874]	PubMed: 38070860
Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity [ Int J Med Sci, 2024, 21(4):755-764]	PubMed: 38464835
CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output [ Mol Ther, 2022, S1525-0016-2200417-8]	PubMed: 35791879
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury [ Cell Biol Toxicol, 2021, 10.1007/s10565-021-09624-x]	PubMed: 34401974
Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation [ Front Pharmacol, 2021, 12:697483]	PubMed: 34393781

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。