Verapamil HCl

製品コードS4202 バッチS420203

印刷

化学情報

Synonyms

CP-16533-1, (±)-Verapamil

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₇H₃₈N₂O₄.HCl

分子量

491.06

CAS No.

152-11-4

Solubility (25°C)*

体外

DMSO

98 mg/mL (199.56 mM)

Water

98 mg/mL (199.56 mM)

Ethanol

98 mg/mL (199.56 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.Verapamil (CP-16533-1) HCl can be used to induce animal models of Heart Failure.
in vitro	The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).
in vivo	Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/23648675/
https://pubmed.ncbi.nlm.nih.gov/23951191/
https://pubmed.ncbi.nlm.nih.gov/29523051/

カスタマーフィードバック

: Data from [Data independently produced by , , Front Pharmacol, 2018, 9:1298]

: Data from [Data independently produced by , , BMC Cancer, 2015, 15:553.]

: Data from [Data independently produced by , , Exp Hematol, 2017, 2.436]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups [ Cancer Cell, 2025, 43(4):776-796.e14]	PubMed: 40185092
Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics [ Nat Commun, 2025, 16(1):7115]	PubMed: 40753165
Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells [ Blood Sci, 2025, 7(2):e00236]	PubMed: 40416726
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805]	PubMed: 39581704
A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers [ NPJ Precis Oncol, 2024, 8(1):94]	PubMed: 38654141
Coumarins with Different Substituents from Leonurus japonicus Have Opposite Effects on Uterine Smooth Muscle [ Int J Mol Sci, 2024, 25(18)10162]	PubMed: 39337649
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway [ Biomedicines, 2024, 12(4)904]	PubMed: 38672259
Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer [ Cancers (Basel), 2023, 15(15)3774]	PubMed: 37568590
Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy [ EMBO Mol Med, 2022, 14(2):e14903]	PubMed: 35023619
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch [ Cell Rep, 2022, 38(10):110468]	PubMed: 35263588

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。