Verapamil HCl

製品コードS4202 バッチS420205

印刷

化学情報

Synonyms

CP-16533-1, (±)-Verapamil

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₇H₃₈N₂O₄.HCl

分子量

491.06

CAS No.

152-11-4

Solubility (25°C)*

体外

DMSO

98 mg/mL (199.56 mM)

Water

98 mg/mL (199.56 mM)

Ethanol

49 mg/mL (99.78 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	4.9mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 98 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.83mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 16.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
in vitro	The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).
in vivo	Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

プロトコル(参考用のみ)

参考

カスタマーフィードバック

: Data from [Data independently produced by , , Front Pharmacol, 2018, 9:1298]

: Data from [Data independently produced by , , BMC Cancer, 2015, 15:553.]

: Data from [Data independently produced by , , Exp Hematol, 2017, 2.436]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。