Vinblastine sulfate

製品コードS4505 バッチS450502

印刷

化学情報

Chemical Structure Synonyms NSC-49842, Vincaleukoblastine, 29060-LE Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C46H58N4O9.H2SO4
分子量 909.05 CAS No. 143-67-9
Solubility (25°C)* 体外 DMSO 100 mg/mL (110.0 mM)
Water (warmed with 50ºC water bath) 50 mg/mL (55.0 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Vinblastine sulfateは、無細胞アッセイにおいて8.9 μMのIC50で微小管形成を阻害し、nAChR活性を抑制し、特定のがん種の治療に使用されます。Vinblastine sulfateはオートファジーとアポトーシスを誘発します。
in vitro The average terminal half-lives of Vinblastine sulfate is 14.3 h. When incubated in freshly isolated rat hepatocytes, this compound penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding. It inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block. This chemical gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC.
in vivo Vinblastine is a widely used anticancer drug with undesired side effects . A combination of this compound and RAP at very low doses against human HCC gets a satisfactory antiangiogenic effect in vivo. The clinically relevant dose of this chemical inhibits palmitoylation of tubulin in vivo in CEM cells (effect on depalmitoylation of tubulin).

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Chinese hamster ovary (CHO) cells
濃度 1% (v/v) (dissolved in DMSO)
反応時間 3h
実験の流れ

Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with this compound for 3 h followed by 21 h growth.

参考

  • https://pubmed.ncbi.nlm.nih.gov/8516349/
  • https://pubmed.ncbi.nlm.nih.gov/19666138/
  • https://pubmed.ncbi.nlm.nih.gov/2088769/
  • https://pubmed.ncbi.nlm.nih.gov/14508526/
  • https://pubmed.ncbi.nlm.nih.gov/17202812/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Induction of cell death by the CXCR2 antagonist SB225002 in colorectal cancer and stromal cells [ Biomed Pharmacother, 2025, 188:118203] PubMed: 40412356
Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury [ Int J Mol Sci, 2025, 26(8)3864] PubMed: 40332566
Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin [ J Mol Cell Biol, 2025, mjaf023] PubMed: 40795355
Eribulin Induction of Immunogenic Cell Death (ICD): Comparison With Other Cytotoxic Agents and Temporal Relationship of ICD Biomarkers [ Anticancer Res, 2025, 45(1):39-53] PubMed: 39740820
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862] PubMed: 39319271
A BPTF Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Murine Triple-Negative Breast Cancer Cells to Chemotherapy [ Int J Mol Sci, 2024, 25(21)11346] PubMed: 39518898
3-nitropyridine analogues as novel microtubule-targeting agents [ PLoS One, 2024, 19(11):e0307153] PubMed: 39509402
A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening [ Nat Commun, 2023, 14(1):7576] PubMed: 37990016
Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response [ J Immunother Cancer, 2023, 11(8)e007253] PubMed: 37652576
Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response [ J Immunother Cancer, 2023, 10.1136/jitc-2023-007253] PubMed: 37652576

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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