Vinorelbine ditartrate

製品コードS4269 バッチS426903

印刷

化学情報

Synonyms

KW-2307 ditartrate

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₄₅H₅₄N₄O₈.2C₄H₆O₆

分子量

1079.11

CAS No.

125317-39-7

Solubility (25°C)*

体外

DMSO

100 mg/mL (92.66 mM)

Water (warmed with 50ºC water bath)

100 mg/mL (92.66 mM)

Ethanol (warmed with 50ºC water bath)

100 mg/mL (92.66 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
in vitro	Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. ^[1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. ^[2]^[3]^[4]
in vivo	In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. ^[5]
特徴	A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	CCLE cell lines
	濃度	39.9 nM
	反応時間
	実験の流れ	Cells were treated with various concentrations of drug.
動物実験	動物モデル	Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.
	投薬量	~10 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/2496470/
https://pubmed.ncbi.nlm.nih.gov/1577845/
https://pubmed.ncbi.nlm.nih.gov/24083716/

https://pubmed.ncbi.nlm.nih.gov/23320984/
https://pubmed.ncbi.nlm.nih.gov/10448309/
https://pubmed.ncbi.nlm.nih.gov/36139690/

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カスタマーフィードバック

: , , Cynthia Bernia from McGill University

: Data from [Data independently produced by , , Mol Cancer Ther, 2016, 15(8):1823-33.]

: Data from [Data independently produced by , , J Biol Chem, 2017, 292(19):7806-7816]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Selective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma [ Commun Biol, 2025, 8(1):152]	PubMed: 39893253
Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway [ Sci Rep, 2025, 15(1):11372]	PubMed: 40175588
Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer [ Cell Death Dis, 2024, 15(8):603]	PubMed: 39164278
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862]	PubMed: 39319271
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment [ BMC Pharmacol Toxicol, 2024, 25(1):25]	PubMed: 38444002
A precision oncology-focused deep learning framework for personalized selection of cancer therapy [ bioRxiv, 2024, 2024.12.12.628190]	PubMed: 39763776
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176]	PubMed: 37773750
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers [ J Pathol, 2023, 261(3):256-268]	PubMed: 37565350
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner [ Cell Oncol (Dordr), 2023, 10.1007/s13402-023-00786-w]	PubMed: 37014551

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。