Vitamin E

製品コードS4686 バッチS468603

印刷

化学情報

Chemical Structure Synonyms Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol Storage
(From the date of receipt)		 2 years  -20°C  liquid
化学式

C29H50O2
分子量 430.71 CAS No. 59-02-9
Solubility (25°C)* 体外  
 
 
体内 （毎回新しく調製した物を用意してください）
Clear solution
5% DMSO 95% Corn oil

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

 7.500mg/ml (17.41mM) Taking the 1 mL working solution as an example, add 50 μL of 150 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
in vitro

this compound is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].
in vivo

Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. This compound reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].
密度 0.95 g/mL at 25 °C

プロトコル(参考用のみ)

細胞アッセイ 細胞株 TC-1 cells
濃度 0, 25, 50 μM
反応時間 18 h
実験の流れ

For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.
動物実験 動物モデル C57BL/6 mice 
投薬量 2 mg/kg
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/25072795/
  • https://pubmed.ncbi.nlm.nih.gov/11160566/
  • https://pubmed.ncbi.nlm.nih.gov/12069504/

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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