受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | Apigenin-8-C-glucoside | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C21H20O10 |
|||
分子量 | 432.38 | CAS No. | 3681-93-4 | |
Solubility (25°C)* | 体外 | DMSO | 86 mg/mL (198.89 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity. |
---|---|
in vitro | Vitexin promotes cell viability, inhibits apoptosis, and decreases inflammatory cytokines. These protective effects are related to the regulation of ER stress by vitexin in chondrocytes[2]. |
in vivo | Vitexin ameliorates sexual dysfunction and fertility impairments in male diabetic mice possibly by modulating the hypothalamus-pituitary-gonadal axis[1]. |
細胞アッセイ | 細胞株 | Chondrocytes |
---|---|---|
濃度 | 0-100 μM | |
反応時間 | 24 h | |
実験の流れ | Chondrocytes (2 × 105 cells) were planted in a 96-well plate and treated with various doses of vitexin, with or without IL-1β (10 ng/mL), for 1 day according to the requirements of the experiment. All of the chondrocytes were incubated for 2 h with cholecystokinin octapeptide (CCK-8) (10 µL) and the absorbance of the reaction at 450 nm was then quantified using a micro-plate reader. |
|
動物実験 | 動物モデル | adult male mice (25–30 g) |
投薬量 | 10, 20 and 40 mg/kg | |
投与方法 | oral |
Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway [ Immunopharmacol Immunotoxicol, 2020, 42(6):594-603] | PubMed: 33045867 |
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway [ Drug Des Devel Ther, 2018, 12:565-573] | PubMed: 29588573 |
Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. [ Mol Med Rep, 2018, 17(3):4599-4604] | PubMed: 29328424 |
Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. [ Oncotarget, 2016, 7(51):84520-84532] | PubMed: 27588401 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。