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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | ||||||||
化学式 | C18H13F2N3O3S |
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分子量 | 389.38 | CAS No. | 2055397-28-7 | ||||||||
Solubility (25°C)* | 体外 | DMSO | 78 mg/mL (200.31 mM) | ||||||||
Water | Insoluble | ||||||||||
Ethanol | Insoluble | ||||||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. |
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in vitro | Treatment of MEFs with WM-1119 resulted in cell cycle arrest in G1 and a senescence phenotype. Treatment with WM-1119 inhibits the proliferation of the EMRK1184 lymphoma cells in vitro. Treatment with WM-1119 results in increased levels of Cdkn2a and Cdkn2b mRNA and p16INK4a and p19ARF proteins, as well as a delayed increase in Cdkn1a mRNA[1]. |
in vivo | WM-1119 is effective in treating lymphoma in vivo while its treatment has no effect on haematocrit, erythrocytes or platelet numbers, but there was overall leukopenia[1]. |
MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor [ Cancer Discov, 2022, candisc.0646.2021] | PubMed: 35499757 |
KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1 [ Theranostics, 2021, 11(13):6278-6292] | PubMed: 33995658 |
KAT6A is associated with sorafenib resistance and contributes to progression of hepatocellular carcinoma by targeting YAP [ Biochem Biophys Res Commun, 2021, 585:185-190] | PubMed: 34808502 |
Lysine acetylation participates in boar spermatozoa motility and acrosome status regulation under different glucose conditions [ Theriogenology, 2021, 159:140-146] | PubMed: 33152539 |
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model [ J Med Chem, 2020, 31] | PubMed: 32191458 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。