WZB117

製品コードS7927 バッチS792703

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₀H₁₃FO₆

分子量

368.31

CAS No.

1223397-11-2

Solubility (25°C)*

体外

DMSO

73 mg/mL (198.2 mM)

Ethanol

73 mg/mL (198.2 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.000mg/ml (2.72mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM.
in vitro	WZB117 inhibits glucose transport in human red blood cells. Cancer cell treatment with this compound leads to decreases in levels of Glut1 protein, intracellular ATP, and glycolytic enzymes. All these changes are followed by increase in ATP-sensing enzyme AMP-activated protein kinase (AMPK) and declines in cyclin E2 as well as phosphorylated retinoblastoma, resulting in cell-cycle arrest, senescence, and necrosis^[1].
in vivo	Daily intraperitoneal injection of WZB117 at 10mg/kg resultes in 70% reduction in tumor volume of human A549 lung cancer grafted on nude mice^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	cancer cell
	濃度	10μM
	反応時間	24 or 48 hours
	実験の流れ	Cells are treated with compound WZB117 for 24 or 48 hours. Mock-treated and glucose deprivation samples served as negative and positive controls, respectively.
動物実験	動物モデル	Nude mice
	投薬量	10mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/22689530/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α [ Nat Commun, 2025, 16(1):4929]	PubMed: 40436847
Drug screening on digital microfluidics for cancer precision medicine [ Nat Commun, 2024, 15(1):4363]	PubMed: 38778087
GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury [ Am J Pathol, 2024, S0002-9440(24)00116-0]	PubMed: 38548270
Activation of cellular antioxidative stress and migration activities by purified components from immortalized stem cells from human exfoliated deciduous teeth [ Sci Rep, 2024, 14(1):15340]	PubMed: 38961142
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response [ Cell Rep, 2023, 42(3):112186]	PubMed: 36870057
De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer [ Cancer Lett, 2022, S0304-3835(22)00321-4]	PubMed: 35921972
WZB117 enhanced the anti-tumor effect of apatinib against melanoma via blocking STAT3/PKM2 axis [ Front Pharmacol, 2022, 13:976117]	PubMed: 36188586
Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells [ Oncol Rep, 2022, 47(1)7]	PubMed: 34738628
Physiologic Mechanical Stress Directly Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt-Related Transcription Factor 2 (Runx2) [ Int J Mol Sci, 2021, 22(16)9070]	PubMed: 34445787
Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice [ Neurosci Bull, 2021, 10.1007/s12264-020-00624-1]	PubMed: 33415566

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。