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Synonyms | Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C30H43FN4O11 |
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分子量 | 654.68 | CAS No. | 210344-98-2 | ||||
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (152.74 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific Caspase-8 inhibitor. Z-IETD-FMK is also an inhibitor of granzyme B. |
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in vitro | Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. [3] |
in vivo | In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. [3] Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. [4] |
細胞アッセイ | 細胞株 | Rat neonatal cardiomyocytes |
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濃度 | 50 µM | |
反応時間 | 24 h | |
実験の流れ | Drugs were added to the cell culture medium simultaneously with ceramide, and surviving cells were counted 24 hours later. |
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動物実験 | 動物モデル | T. cruzi-infected mice |
投薬量 | 0.4 mg/3 days | |
投与方法 | -- |
Data from [Data independently produced by , , Cell Physiol Biochem, 2017, 42(5):1822-1836]
Data from [Data independently produced by , , Int J Oncol, 2018, 52(3):1023-1032]
Data from [Data independently produced by , , Drug Des Devel Ther, 2017, 11:2841-2850]
EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death [ Nat Commun, 2024, 15(1):1282] | PubMed: 38346956 |
ERK mediates interferon gamma-induced melanoma cell death [ Mol Cancer, 2023, 10.1186/s12943-023-01868-x] | PubMed: 37803324 |
THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass [ Nat Commun, 2023, 14(1):1020] | PubMed: 36823211 |
Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation [ Cell Rep Med, 2023, 4(7):101098] | PubMed: 37390829 |
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding [ SCIENCE ADVANCES, 2023, Vol-9,-Issue-12] | PubMed: None |
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding [ SCIENCE ADVANCES, 2023, Vol-9,-Issue-12] | PubMed: None |
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2 [ EMBO J, 2023, e113118.] | PubMed: 37646198 |
Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates [ EMBO J, 2023, e113490.] | PubMed: 36920246 |
Immunostimulatory oncolytic activity of coxsackievirus A11 in human malignant pleural mesothelioma [ Cancer Sci, 2023, 114(3):1095-1107] | PubMed: 36369966 |
AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer [ J Cell Mol Med, 2023, 27(16):2412-2423] | PubMed: 37438979 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。