Z-VAD(OH)-FMK (Caspase Inhibitor VI)

製品コードS8102 バッチS810202

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H28FN3O7
分子量 453.46 CAS No. 161401-82-7
Solubility (25°C)* 体外 DMSO 90 mg/mL (198.47 mM)
Ethanol 90 mg/mL (198.47 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
in vitro

Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1]
in vivo

Z-VAD-FMK is a widely used broad-spectrum caspase inhibitor that protects muscle from compression-induced damage and restores muscle function.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Panc-1 cells
濃度 50 μM
反応時間 1 h
実験の流れ

Cells were treated with indicated concentration of the drug for an hour.
動物実験 動物モデル Male BALB/C mice
投薬量 1.5 mg/kg
投与方法 s.c.

カスタマーフィードバック

Data from [Data independently produced by , , Med Oncol, 2015, 32(4):100. ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA [ J Ethnopharmacol, 2024, 328:118057] PubMed: 38518965
Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells [ Toxins (Basel), 2024, 16(1)61] PubMed: 38276537
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis [ Commun Biol, 2023, 6(1):1271] PubMed: 38102401
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors [ Cell Death Dis, 2022, 13(11):1000] PubMed: 36435804
Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy [ Free Radic Biol Med, 2022, S0891-5849(22)00222-2] PubMed: 35675856
Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation [ Int J Mol Sci, 2022, 23(16)8839] PubMed: 36012104
Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells [ Int J Biol Sci, 2021, 17(2):589-602] PubMed: 33613115
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer [ Cell Death Dis, 2021, 12(2):140] PubMed: 33542218
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity [ EMBO Rep, 2021, 22(2):e51162] PubMed: 33393230
Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. [ Nat Commun, 2019, 10(1):4040] PubMed: 31492859

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。